Adenosine
SIGMA/A4036 - BioReagent, suitable for cell culture
Synonym: 9-β-D-Ribofuranosyladenine; Adenine riboside; Adenine-9-β-D-ribofuranoside
CAS Number: 58-61-7
Empirical Formula (Hill Notation): C10H13N5O4
Molecular Weight: 267.24
EC Number: 200-389-9
MDL Number: MFCD00005752
Linear Formula: C10H13N5O4
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A4036-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A4036-5G
| assay | ≥99% (HPLC) |
| biological source | synthetic (organic) |
| form | powder |
| InChI | 1S/C10H13N5O4/c11-8-5-9(1 |
| InChI key | OIRDTQYFTABQOQ-KQYNXXCUSA |
| mp | 234-236 °C (lit.) |
| product line | BioReagent |
| Quality Level | 300  |
| SMILES string | Nc1ncnc2n(cnc12)[C@@H]3O[ |
| solubility | 1 M NH4OH: 50 mg/mL, clear, colorless |
| storage temp. | 2-8°C |
| technique(s) | cell culture | mammalian: suitable |
| Application: | Adenosine has been used as a supplement in DMEM (Dulbecco′s modified Eagle medium): • to evaluate the outgrowth of the interspecies somatic cell nucleus transfer (iSCNT)-derived blastocysts • to maintain the CGR8 ES (germ-line competent cell line) cells • for plasmid transfection and cloning of embryonic stem cells |
| Biochem/physiol Actions: | Endogenous neurotransmitter at adenosine receptors. Cardioprotective effects may relate to activation of A1 adenosine receptors. The antiplatelet and anti−inflammatory actions of adenosine appear to be mediated via the A2 adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD). |
| Biochem/physiol Actions: | Endogenous neurotransmitter. Cardioprotective effects may relate to activation of A1 adenosine receptors. The antiplatelet and anti−inflammatory actions of adenosine appear to be mediated via the A2 adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD). |
| Biochem/physiol Actions: | Tissue injury, ischemia and abnormal cell proliferation stimulate the release of adenosine. Adenosine helps in countering the effects of reduced oxygen and energy in organs such as heart, brain and skeletal muscles mediating vasodialation. It delivers its action through G protein-coupled receptors. Adenosine also reduces the release of neurotransmitters and cellular metabolism. |
| General description: | The nucleoside adenosine consists of the purine adenine and the sugar ribose. Thus, it is also referred as adenine-D-ribose. Adenosine is an important molecule that forms nucleotides, which is a part of nucleic acids forming the DNA and RNA. The nucleotides include: adenosine monophosphate, adenosine diphosphate and adenosine triphosphate. |
| Packaging: | 5, 25 g in poly bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% (HPLC) |
| mp | 234-236 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352207 |