Ara-G hydrate
SIGMA/A4233 - ≥98% (HPLC), solid
Synonym: 9-β-D-Arabinofuranosyl guanine hydrate
CAS Number: 38819-10-2 (anhydrous)
Empirical Formula (Hill Notation): C10H13N5O5 · xH2O
Molecular Weight: 283.24 (anhydrous basis)
MDL Number: MFCD00065486
Linear Formula: C10H13N5O5 · xH2O
Product Type: Chemical
assay | ≥98% (HPLC) |
form | solid |
InChI | 1S/C10H13N5O5/c11-10-13-7 |
InChI key | NYHBQMYGNKIUIF-FJFJXFQQSA |
Quality Level | 100 |
SMILES string | NC1=Nc2c(ncn2[C@@H]3O[C@H |
solubility | DMSO: >10 mg/mL |
H2O: insoluble | |
storage temp. | 2-8°C |
Application: | Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. This active form of Ara-G induces apoptosis and inhibits DNA synthesis. Ara-G is also an antineoplastic and antimetabolite. |
Biochem/physiol Actions: | Ara-G is an inducer of apoptosis; inhibitor of DNA synthesis; antineoplastic; and antimetabolite. Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. Incorporation of Ara-GTP into DNA leads to inhibition of DNA synthesis and apoptosis. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H302 - H315 - H319 - H335 |
Precautionary statements | P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 |
Hazard Codes | Xn |
Risk Statements | 22-36/37/38 |
Safety Statements | 26 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |