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Ara-G hydrate

SIGMA/A4233 - ≥98% (HPLC), solid

Synonym: 9-β-D-Arabinofuranosyl guanine hydrate

CAS Number: 38819-10-2 (anhydrous)
Empirical Formula (Hill Notation): C10H13N5O5 · xH2O
Molecular Weight: 283.24 (anhydrous basis)
MDL Number: MFCD00065486
Linear Formula: C10H13N5O5 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A4233-5MG 5 mg
 $161.00
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45-A4233-25MG 25 mg
 $614.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
form solid
InChI 1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6+,9-/m1/s1
InChI key NYHBQMYGNKIUIF-FJFJXFQQSA-N
Quality Level 100 
SMILES string NC1=Nc2c(ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O)C(=O)N1
solubility DMSO: >10 mg/mL
  H2O: insoluble
storage temp. 2-8°C
Application: Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. This active form of Ara-G induces apoptosis and inhibits DNA synthesis. Ara-G is also an antineoplastic and antimetabolite.
Biochem/physiol Actions: Ara-G is an inducer of apoptosis; inhibitor of DNA synthesis; antineoplastic; and antimetabolite.
Biochem/physiol Actions: Ara-G is an inducer of apoptosis; inhibitor of DNA synthesis; antineoplastic; and antimetabolite. Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. Incorporation of Ara-GTP into DNA leads to inhibition of DNA synthesis and apoptosis.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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