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S-(5′-Adenosyl)-L-methionine iodide

SIGMA/A4377 - ≥80% (HPLC), ≥80% (spectrophotometric assay)

Synonym: AdoMet; SAM

CAS Number: 3493-13-8
Empirical Formula (Hill Notation): C15H23IN6O5S
Molecular Weight: 526.35
EC Number: 222-486-5
MDL Number: MFCD00043192
Linear Formula: C15H23IN6O5S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A4377-5MG 5 mg
 $80.70
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45-A4377-25MG 25 mg
 $229.00
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45-A4377-100MG 100 mg
 $711.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A4377-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A4377-25MG

 

assay ≥80% (HPLC)
  ≥80% (spectrophotometric assay)
color white to off-white
form powder
InChI 1S/C15H22N6O5S.HI/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);1H/t7-,8+,10+,11+,14+,27?;/m0./s1
InChI key XQMWYLXPEGFCFT-XKGORWRGSA-N
Quality Level 200 
shipped in dry ice
SMILES string [I-].C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
solubility H2O: 100 mg/mL
storage temp. −20°C
technique(s) cell culture | mammalian: suitable
Analysis Note: Purity based on UV and HPLC.
Application: S-(5′-Adenosyl)-L-methionine (SAM, AdoMet) is used as a primary methyl donor molecule in mammalian cell culture and the first step metabolite in methionine biosynthesis.
Biochem/physiol Actions: Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
Caution: This material is very unstable at room temperature.
Packaging: 5, 25, 100 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H317
Precautionary statements P280
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥80% (HPLC); ≥80% (spectrophotometric assay)
Storage Temp. −20°C
UNSPSC 12352209

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