L-Ascorbic acid
SIGMA/A4403 - powder, suitable for cell culture, γ-irradiated
Synonym: L-Threoascorbic acid; Antiscorbutic factor; Vitamin C
CAS Number: 50-81-7
Empirical Formula (Hill Notation): C6H8O6
Molecular Weight: 176.12
EC Number: 200-066-2
MDL Number: MFCD00064328
Linear Formula: C6H8O6
Product Type: Chemical
| biological source | synthetic (organic) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C6H8O6/c7-1-2(8)5-3(9) |
| InChI key | CIWBSHSKHKDKBQ-JLAZNSOCSA |
| mol wt | Mw 176.12 g/mol |
| mp | 190-194 °C (dec.) |
| pH | 1.0-2.5 (25 °C, 176 g/L in water) |
| Quality Level | 200  |
| SMILES string | OC([C@]([C@@H](O)CO)([H]) |
| solubility | H2O: 10 mg/mL |
| sterility | γ-irradiated |
| technique(s) | cell culture | insect: suitable |
| cell culture | mammalian: suitable | |
| cell culture | plant: suitable |
| Application: | For use in cell culture applications as an antioxidant and to regenerate tocopherol. L-ascorbic acid has been used: • in an osteogenic supplement for the growth of cells • as a component in the differentiation media • in WS-MSCs (Werner syndrome-mesenchymal stem cells) to study rescuing properties of ascorbic acid on aging defects |
| Biochem/physiol Actions: | L-ascorbic acid mainly exhibits antioxidant properties. It protects plants from oxidative stress and mammals from diseases associated with oxidative stress. L-ascorbic acid mainly protects from hydroxyl radicals, superoxide and singlet oxygen. In addition, it also reduces the membrane-linked antioxidant α-tocopherol (oxidised form). L-Ascorbic acid enhances endothelium-dependent vasodilation in various disorders, including diabetes, coronary artery disease, hypertension and chronic heart failure. |
| General description: | L-ascorbic acid is an unsaturated γ-lactone ring containing an enediol configuration (–COH=COH) attached with a carbonyl group. |
| Other Notes: | 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research  |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| mp | 190-194 °C (dec.) |
| UNSPSC | 12352207 |