6-Thioguanine
SIGMA/A4660 - Hybri-Max™, 50 ×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma
Synonym: 2-
CAS Number: 154-42-7
Empirical Formula (Hill Notation): C5H5N5S
Molecular Weight: 167.19
EC Number: 205-827-2
MDL Number: MFCD00233553
Linear Formula: C5H5N5S
Product Type: Chemical
| assay | ~98% |
| biological source | synthetic (organic) |
| concentration | 50 × |
| form | lyophilized powder |
| grade | Hybri-Max™ |
| impurities | endotoxin, tested |
| InChI | 1S/C5H5N5S/c6-5-9-3-2(4(1 |
| InChI key | WYWHKKSPHMUBEB-UHFFFAOYSA |
| mp | ≥300 °C (lit.) |
| product line | BioXtra |
| Quality Level | 200  |
| SMILES string | NC1=Nc2nc[nH]c2C(=S)N1 |
| solubility | 1 M NaOH: 50 mg/mL, clear to slightly hazy |
| sterility | γ-irradiated |
| storage temp. | room temp |
| technique(s) | cell culture | hybridoma: suitable |
| Application: | Used in hybridoma formation applications as a selection agent. |
| Biochem/physiol Actions: | Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia. |
| Legal Information: | Hybri-Max is a trademark of Sigma-Aldrich Co. LLC |
| Reconstitution: | Reconstitute contents of vial with 10 ml sterile cell culture medium. Stock solution is sufficient to prepare 500 ml medium. Final working concentration: 30 μM 2-amino-6-mercaptopurine. |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P310 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 28-36/37/39-45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ~98% |
| mp | ≥300 °C (lit.) |
| Storage Temp. | room temp |
| UNSPSC | 12352207 |