Alsterpaullone
SIGMA/A4847 - ≥98% (HPLC), powder
Synonym: 9-
CAS Number: 237430-03-4
Empirical Formula (Hill Notation): C16H11N3O3
Molecular Weight: 293.28
MDL Number: MFCD02683579
Linear Formula: C16H11N3O3
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | yellow to brown |
| form | powder |
| InChI | 1S/C16H11N3O3/c20-15-8-12 |
| InChI key | OLUKILHGKRVDCT-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | [O-][N+](=O)c1ccc2[nH]c-3 |
| solubility | DMSO: ≥10 mg/mL |
| storage condition | desiccated |
| storage temp. | 2-8°C |
| Application: | Alsterpaullone has been used to stabilize β-catenin. |
| Application: | Alsterpaullone inhibits GSK-3β, CDK5/p25, and CDK1/cyclin B. Alsterpaullone has also been studied as an antimanic therapeutic for the acute manic phase of bipolar disorder. |
| Biochem/physiol Actions: | Alsterpaullone (ALP) is a cyclin-dependent kinase (CDK) inhibitor. It is considered as a therapeutic agent for group 3 medulloblastomas. Alsterpaullone modulates the progression of cell cycle. It can arrest cell cycle and stimulate the apoptosis of cancer cells by activating caspase-9 through perturbation of mitochondrial membrane potential. |
| Biochem/physiol Actions: | Potent and selective inhibitor of GSK-3β and CDK5/p25; potent inhibitor of CDK1/cyclin B (IC50 = 0.035 μM). |
| Features and Benefits: | This compound is featured on the CDKs and GSK-3 pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 1 mg in glass bottle |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |