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Alendronate sodium trihydrate

SIGMA/A4978 - ≥97% (NMR), powder

Synonym: 4-amino-1-hydroxy-1-phosphonobutyl phosphonic acid, monosodium; MK-217

CAS Number: 121268-17-5
Empirical Formula (Hill Notation): C4H12NaNO7P2 · 3 H2O
Molecular Weight: 325.12
MDL Number: MFCD01748233
Linear Formula: C4H12NaNO7P2 · 3 H2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A4978-100MG 100 mg
 $263.00
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assay ≥97% (NMR)
color white
form powder
InChI 1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1
InChI key DCSBSVSZJRSITC-UHFFFAOYSA-M
Quality Level 100 
SMILES string [Na+].[H]O[H].[H]O[H].[H]O[H].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O
solubility water, double-distilled: 10 mg/mL
storage temp. −20°C
Application: Alendronate sodium trihydrate has been used:• for calcium phosphate nanoparticles (nCaP)/ bisphosphonate (BP) coating on titanium implants and analyze its osteogenic capacity
• in osteogenic differentiation of human bone marrow stromal cells (hBMSCs) isolated from aged osteoporosis patients- and healthy-person
• to treat osteoblast progenitor cells and osteoblasts and study their effect on osteoblast behaviors using conventional assays and simple digital image analysis
Biochem/physiol Actions: Alendronate is a nitrogen-containing bisphosphonate that is known to hinder the mevalonate pathway and limit osteoclastic function and activity. Alendronate sodium trihydrate is a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor, and CD45 protein tyrosine phosphatase inhibitor.
Biochem/physiol Actions: Alendronate sodium trihydrate is a bone resorption inhibitor; farnesyl diphosphate synthase inhibitor (IC50 = 460 nM); CD45 protein tyrosine phosphatase inhibitor.
Packaging: 100 mg in glass bottle
Preparation Note: Following reconstitution, it is recommended to aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (NMR)
Storage Temp. −20°C
UNSPSC 41106300

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