Alendronate sodium trihydrate
SIGMA/A4978 - ≥97% (NMR), powder
Synonym: 4-
CAS Number: 121268-17-5
Empirical Formula (Hill Notation): C4H12NaNO7P2 · 3 H2O
Molecular Weight: 325.12
MDL Number: MFCD01748233
Linear Formula: C4H12NaNO7P2 · 3 H2O
Product Type: Chemical
assay | ≥97% (NMR) |
color | white |
form | powder |
InChI | 1S/C4H13NO7P2.Na.3H2O/c5- |
InChI key | DCSBSVSZJRSITC-UHFFFAOYSA |
Quality Level | 100 |
SMILES string | [Na+].[H]O[H].[H]O[H].[H] |
solubility | water, double-distilled: 10 mg/mL |
storage temp. | −20°C |
Application: | Alendronate sodium trihydrate has been used:• for calcium phosphate nanoparticles (nCaP)/ bisphosphonate (BP) coating on titanium implants and analyze its osteogenic capacity • in osteogenic differentiation of human bone marrow stromal cells (hBMSCs) isolated from aged osteoporosis patients- and healthy-person • to treat osteoblast progenitor cells and osteoblasts and study their effect on osteoblast behaviors using conventional assays and simple digital image analysis |
Biochem/physiol Actions: | Alendronate is a nitrogen-containing bisphosphonate that is known to hinder the mevalonate pathway and limit osteoclastic function and activity. Alendronate sodium trihydrate is a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor, and CD45 protein tyrosine phosphatase inhibitor. |
Biochem/physiol Actions: | Alendronate sodium trihydrate is a bone resorption inhibitor; farnesyl diphosphate synthase inhibitor (IC50 = 460 nM); CD45 protein tyrosine phosphatase inhibitor. |
Packaging: | 100 mg in glass bottle |
Storage and Stability: | Following reconstitution, it is recommended to aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C. |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H302 |
Hazard Codes | Xn |
Risk Statements | 22 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥97% (NMR) |
Storage Temp. | −20°C |
UNSPSC | 41106300 |