3-Acetylpyridine adenine dinucleotide
SIGMA/A5251 - ≥85%
Synonym: 3 -Acetyl NAD; APADH; APAD
CAS Number: 86-08-8
Empirical Formula (Hill Notation): C22H28N6O14P2
Molecular Weight: 662.44
MDL Number: MFCD00078882
Linear Formula: C22H28N6O14P2
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A5251-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A5251-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A5251-25MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A5251-500MG
| λmax | 259-260 nm |
| assay | ≥85% |
| biological source | Porcine brain |
| color | white to off-white |
| concentration | ≤100% (3-acetylpyridine-adenine dinucleotide) |
| fluorescence | λem 15.2- 17.2 (dry basis at pH 7.0) |
| form | powder |
| InChI | 1S/C22H28N6O14P2/c1-10(29 |
| InChI key | KPVQNXLUPNWQHM-RBEMOOQDSA |
| mol wt | 662.44 g/mol |
| Quality Level | 200  |
| SMILES string | CC(=O)c1ccc[n+](c1)[C@@H] |
| solubility | water: 50 mg/mL, clear, colorless to faintly yellow |
| storage temp. | −20°C |
| Application: | Many molecules use 3-Acetylpyridine adenine dinucleotide as a signaling molecule, cofactor, or substrate. Various dehydrogenase processes use APAD instead of NAD as a hydrogen-accepting cofactor. The oxidative phosphorylation can be studied with ADAP. ADAP can also be used as a suitable substrate. |
| Biochem/physiol Actions: | APAD is an NAD analog with higher oxidation potential than NAD. It can substitute for NAD as a hydrogen-accepting cofactor in many dehydrogenase reactions; e.g. lactate dehydrogenase from Toxoplasma, Clonorchis, and Plasmodium, bacterial lipoamide dehydrogenase, as well as mammalian dehydrogenases. It can also act as a proton acceptor in various transhydrogenation reactions with NADH or NADPH. |
| General description: | 3-Acetylpyridine adenine dinucleotide is a crystalline solid. 3-Acetylpyridine adenine dinucleotide is a prominent electron transporter in various enzymatic activities in which it is alternately oxidized. APAD has a more significant oxidation potential than NAD. NAD analogues, APAD, were electrochemically more effectively reduced than genuine NAD, and the stability of their reduced products was also significantly higher than NADH. In transhydrogenation processes with NADH or NADPH, APAD also operates as a proton acceptor. |
| Other Notes: | Analog of NAD |
| Packaging: | 1 g in glass bottle |
| Packaging: | 25, 100, 500 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥85% |
| Storage Temp. | −20°C |
| UNSPSC | 41106305 |