Apolipoprotein B from human plasma

SIGMA/A5353 - ≥95%, lyophilized powder

Synonym: apoB

MDL Number: MFCD00130537
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-A5353-.5MG	0.5 mg	$481.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95%
biological source	human plasma
form	lyophilized powder
Quality Level	200
shipped in	ambient
storage temp.	−20°C
UniProt accession no.	P04114

Application:	The common p.Ile291Val variant of ERLIN1 enhances TM6SF2 function and is associated with protection against MASLD.: This study investigates a variant of ERLIN1 and its role in enhancing TM6SF2 function, highlighting how Apolipoprotein B from human plasma contributes to understanding metabolic-associated liver disease (MASLD) protection (Rendel et al., 2024 ). Blood Lipids, Lipoproteins, and Apolipoproteins With Risk of Coronary Heart Disease: A Prospective Study Among Racially Diverse Populations.: This prospective study evaluates the relationship between blood lipids, lipoproteins, Apolipoprotein B, and the risk of coronary heart disease across diverse populations, providing crucial insights into cardiovascular risk assessment (Deng et al., 2024 ). *The genomic landscape of VkMYC myeloma highlights shared pathways of transformation between mice and humans.**: Research in this paper identifies shared pathways in myeloma transformation between mice and humans, utilizing Apolipoprotein B from human plasma to understand the molecular mechanisms involved in this process (Maura et al., 2024 ).
Biochem/physiol Actions:	Apo-B levels correlate with the risk of coronary disease. Apo-B exists in human plasma in two isoforms, Apo-B48 and Apo-B100. Apo-B100 is the major physiological ligand for the LDL receptor. Apo-B100 is a large monomeric protein, containing 4563 amino acids (MW 515 kDa). Apo-B100 is synthesized in the liver and is required for the assembly of VLDL. It does not interchange between lipoprotein particles, as do the other apolipoproteins, and it is found in IDL and LDL after the removal of the Apo-A, E, and C. Apo-B48 is present in chylomicrons and their remnants. It is essential for the intestinal absorption of dietary lipids. Apo-B48 is synthesized in the small intestine. It comprises approximately half of the N-terminal region of Apo-B100 and is the result of posttranscriptional mRNA editing by a stop codon in the intestine not found in the liver. The concentration of Apo-B in normal plasma is ~90 mg/dl.
Disclaimer:	RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Physical form:	Lyophilized from buffer containing 10 mM sodium deoxycholate, 0.05 M sodium carbonate and 0.05 M sodium chloride, pH 10.0
Preparation Note:	Delipidated with sodium deoxycholate.

Symbol	GHS07
Signal word	Warning
Hazard statements	H319
Precautionary statements	P264 - P280 - P305 + P351 + P338 - P337 + P313
Hazard Codes	Xn
Risk Statements	22-36/37
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥95%
Storage Temp.	−20°C
UNSPSC	12352211

Choose a favorite list for this item:

Catalog Number	Description	Price

		$

Please choose a list :

Continue Shopping

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.