Ampicillin sodium salt
SIGMA/A5354 - Ready Made Solution, 100 mg/mL
Synonym: Aminobenzylpenicillin; Ampicillin; D-(−)-α-Aminobenzylpenicillin sodium salt
CAS Number: 69-52-3
Empirical Formula (Hill Notation): C16H18N3NaO4S
Molecular Weight: 371.39
MDL Number: MFCD00064313
Linear Formula: C16H18N3NaO4S
Product Type: Chemical
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| antibiotic activity spectrum | Gram-negative bacteria |
| Gram-positive bacteria | |
| autoignition temp. | 301 °C |
| biological source | microbial |
| color | colorless to light yellow |
| concentration | 100 mg/mL |
| form | liquid |
| ready-to-use solution | |
| InChI | 1S/C16H19N3O4S.Na/c1-16(2 |
| InChI key | KLOHDWPABZXLGI-YWUHCJSESA |
| mode of action | cell wall synthesis | interferes |
| mp | 215 °C (dec.) (lit.) |
| Quality Level | 200  |
| shipped in | dry ice |
| SMILES string | CC1(C(N2C(S1)C(C2=O)NC(=O |
| [Na+].CC1(C)SC2[C@H](NC(= |
|
| solubility | DMSO: 100 mg/mL |
| storage condition | ( |
| storage temp. | −20°C |
| suitability | suitable (for antibacterial use in culture media) |
| Application: | Ampicillin is used to select bacteria cells with specific resistance during general microbiology studies. It is used to study antibiotic resistance and penetration limitations, the synergy between multiple antibiotics, certain bloodstream infections, and has been used to develop PCR assays to detect resistance genes in cerebrospinal fluid . |
| Biochem/physiol Actions: | Mode of Action: This is a ß-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane.Mode of Resistance: Administration with ß-lactamase cleaves the ß-lactam ring of Ampicillin and inactivates it. Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol. |
| Biochem/physiol Actions: | Mode of Action: This is a ß-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Mode of Resistance: Administration with ß-lactamase cleaves the ß-lactam ring of Ampicillin and inactivates it. Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol. |
| Features and Benefits: | • High-quality antibiotic suitable for multiple research applications • Ideal for Cell Biology and Biochemical research. |
| General description: | Ampicillin, a member of the extended-spectrum β-lactam family, is a semisynthetic derivative of penicillin widely employed as a versatile broad-spectrum antibiotic. Its mechanism of action involves inhibiting bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), disrupting the crucial peptidoglycan synthesis process essential for bacterial cell wall formation. This antibiotic exhibits efficacy against a diverse range of bacteria, including Gram-positive and Gram-negative strains like E. coli, β-lactam sensitive vancomycin-resistant Enterococcus (VRE), Staphylococcus aureus, and Streptococcus pneumoniae.In scientific research, ampicillin assumes a pivotal role, particularly in microbiological, biochemical, and cell biology investigations. Its application in laboratories extends to the exploration of antibiotic resistance and penetration limitations, the study of synergistic interactions among multiple antibiotics, and serving as a vital component for selecting and maintaining recombinant plasmids in E. coli. Ampicillin in a convenient ready-to-use 100 mg/mL in DMSO solution is useful in the selection of bacteria cells with specific resistance. |
| General description: | Chemical structure: ß-lactam |
| Other Notes: | For additional information on our range of Biochemicals , please complete this form . |
| Other Notes: | Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefullyresealed and kept upright to prevent leakage. |
| Symbol |  GHS08 |
| Signal word | Danger |
| Hazard statements | H317 - H334 |
| Precautionary statements | P261 - P272 - P280 - P284 - P302 + P352 - P304 + P340 + P312 |
| Hazard Codes | Xn |
| Risk Statements | 42/43 |
| Safety Statements | 23-36/37-45 |
| WGK Germany | WGK 2 |
| Flash Point(F) | 188.6 °F - closed cup |
| Flash Point(C) | 87 °C - closed cup |
| mp | 215 °C (dec.) (lit.) |
| Storage Temp. | −20°C |
| UNSPSC | 51280000 |