Aristolochic acid I
SIGMA/A5512 - powder
Synonym: TR 1736
CAS Number: 313-67-7
Empirical Formula (Hill Notation): C17H11NO7
Molecular Weight: 341.27
EC Number: 206-238-3
MDL Number: MFCD00004996
Linear Formula: C17H11NO7
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A5512-100MG
| assay | ≥90% (HPLC) |
| color | yellow |
| form | powder |
| InChI | 1S/C17H11NO7/c1-23-12-4-2 |
| InChI key | BBFQZRXNYIEMAW-UHFFFAOYSA |
| mp | 269-270 °C |
| SMILES string | COc1cccc2c1cc([N+]([O-])= |
| solubility | DMSO: soluble |
| ethanol: soluble | |
| storage temp. | 2-8°C |
| Application: | Aristolochic acid I have been used: • as a standard for the analysis of Aristolochia sprucei crude extract by high-performance liquid chromatography • to study its effects on histone deacetylase 3 (HDAC3) aberration and renal fibrosis • to induce acute aristolochic acid nephropathy and to study its impact on miRNA and mRNA expression in mice |
| Biochem/physiol Actions: | Aristolochic acid is a potent inhibitor of phospholipase A2 (PLA2), hyaluronidase, and acetylcholinesterase plasma proteases from snake venoms. Aristolochic acid is considered a herbal medicine and shows therapeutic effects against obstetrics, snake bites, gout, and rheumatism. It exhibits anti-inflammatory and anti-malarial properties. In addition, it is also considered a genotoxic mutagen and causes aristolochic acid nephropathy (AAN), characterized by interstitial fibrosis and urothelial cancer. |
| Biochem/physiol Actions: | Potent phospholipase A2 inhibitor, including calcium ionophore-induced phospholipase A2 activity in neutrophils. Kidney tumor initiator in experimental animal model. |
| General description: | Aristolochic acid is a naturally occurring plant metabolite found in Aristolochia sp, Bragantia sp. or Asarum sp. plants. It comprises a mixture of nitrophenanthrene carboxylic acids such as aristolochic acid I and II. |
| Packaging: | 100 mg in glass bottle |
| Packaging: | 25 mg in poly bottle |
| Symbol |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H301 - H340 - H350 |
| Precautionary statements | P201 - P301 + P310 + P330 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 7-35-45 |
| RIDADR | UN 1544PSN1 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (HPLC) |
| mp | 269-270 °C |
| Storage Temp. | 2-8°C |
| UNSPSC | 41106300 |