N-Acetylprocainamide hydrochloride

SIGMA/A5513 - ≥99% (HPLC), powder

Synonym: N-Acetylnovocainamide hydrochloride; Acecainide hydrochloride; NAPA

CAS Number: 34118-92-8
Empirical Formula (Hill Notation): C₁₅H₂₃N₃O₂ · HCl
Molecular Weight: 313.82
EC Number: 251-831-2
MDL Number: MFCD00012501
Linear Formula: 4-(CH₃CONH)C₆H₄CONHCH₂CH₂N(C₂H₅)₂·HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A5513-1G	1 g	$111.00 1/EA	Add To Favorites
45-A5513-5G	5 g	$380.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A5513-1G

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99% (HPLC)
form	powder
InChI	1S/C15H23N3O2.ClH/c1-4-18(5-2)11-10-16-15(20)13-6-8-14(9-7-13)17-12(3)19;/h6-9H,4-5,10-11H2,1-3H3,(H,16,20)(H,17,19);1H
InChI key	IYEWBJUCJHKLHD-UHFFFAOYSA-N
mp	184-186 °C (lit.)
Quality Level	100
SMILES string	Cl[H].CCN(CC)CCNC(=O)c1ccc(NC(C)=O)cc1
solubility	H₂O: 50 mg/mL
storage temp.	−20°C

Application:	N-Acetylprocainamide hydrochloride may be used: • as an internal standard for spiking plasma samples for ultra-high-pressure liquid chromatography coupled with a diode array detector (UHPLC-DAD) analysis • to test its relaxant effect on tracheal smooth muscle tissue preparations • in preparation of complexes with N-acetyl-L-tyrosine methyl ester and N-acetyl-L-phenylalanine methyl ester for studying intermolecular interactions using nuclear magnetic resonance (NMR) spectroscopy studies
Application:	N-Acetylprocainamide hydrochloride is a class III antiarrhythmic compound. N-Acetylprocainamide hydrochloride has been used in a study to determine the disposition of procainamide and N-acetylprocainamide in protein-calorie malnutrition. N-Acetylprocainamide hydrochloride has also been used to study pharmacokinetics of procainamide and N-acetylprocainamide in rats.
Biochem/physiol Actions:	N-acetyltransferase II in liver catalyzes the conversion of procainamide to N-acetylprocainamide (NAPA).
Biochem/physiol Actions:	Class III antiarrhythmic. Increases the duration of the action potential by decreasing the delayed outward potassium current, slightly decreasing the calcium current, and slightly depressing the inward rectifier potassium current. This is the active metabolite of procainamide that does not induce systemic lupus erythematosus.
Packaging:	1, 5 g in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99% (HPLC)
mp	184-186 °C (lit.)
Storage Temp.	−20°C
UNSPSC	12352200

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