Adenosine 3′,5′-diphosphate disodium salt

SIGMA/A5763 - ≥96%

Synonym: 3′-phosphoadenosine 5′-phosphate; 3′-phosphorylated nucleotide; PAP; 3′-Phosphoadenosine 5′-phosphate; PAP

CAS Number: 75431-54-8
Empirical Formula (Hill Notation): C₁₀H₁₃N₅Na₂O₁₀P₂
Molecular Weight: 471.16
MDL Number: MFCD00057007
Linear Formula: C₁₀H₁₃N₅Na₂O₁₀P₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A5763-10MG	10 mg	$293.00 1/EA	Add To Favorites
45-A5763-25MG	25 mg	$585.00 1/EA	Add To Favorites
45-A5763-100MG	100 mg	$1850.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥96%
biological source	synthetic (inorganic)
form	powder
InChI	1S/C10H15N5O10P2.Na.H/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19;;/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22);;
InChI key	ISROZYFZEAVMSP-UHFFFAOYSA-N
Quality Level	200
SMILES string	[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(O)=O)C(OP(O)(O)=O)C3O
solubility	water: 25 mg/mL, clear, colorless to very faintly yellow
storage temp.	−20°C

Application:	Adenosine 3′,5′-diphosphate disodium salt has been used: • to spot sample on cellulose high-performance thin-layer chromatography (HPTLC) plates in two-dimensional thin layer chromatography • in enzyme activity assay to study the activities of HOS2/FIERY1 wild type • hos2 mutant and fiery1?2 mutant protein against 3′-phosphoadenosine 5′-phosphate (PAP) • as a standard for the quantification of phosphoadenosines
Biochem/physiol Actions:	3′-phosphoadenosine 5′-phosphate (PAP) is capable of blocking exoribonucleases (XRNs) activity in the nucleus and cytosol. It stimulates stomatal closure and can serve as a secondary messenger during abscisic acid (ABA) signaling. It is capable of blocking RNA catabolism. Hence it may serve as a physiological modulator of poly (ADP-ribose) polymerase 1 (PARP1) activity.
Biochem/physiol Actions:	Adenosine 3′,5′-diphosphate (PAP) is used to study the kinetics and mechanisms of hydroxysteroid sulfotransferases such as SULT1A1, SULT2A1 of which it is product inhibitor.
General description:	3′-phosphoadenosine 5′-phosphate (PAP), a 3′-phosphorylated nucleotide is found in almost all organisms and is obtained as a by-product of sulfur and lipid metabolism.
Packaging:	10 mg in glass bottle
Packaging:	25, 100 mg in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-27-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥96%
Storage Temp.	−20°C
UNSPSC	41106305

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