N-Acetyl-Leu-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin

SIGMA/A5845 - ≥95% (HPLC), powder

Synonym: Ac-LEHD-AFC

Empirical Formula (Hill Notation): C₃₃H₃₈O₁₁N₇F₃
Molecular Weight: 765.69
MDL Number: MFCD01862610
Linear Formula: C₃₃H₃₈O₁₁N₇F₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-A5845-5MG	5 mg	$526.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
color	white
form	powder
InChI	1S/C33H38F3N7O11/c1-15(2)8-22(39-16(3)44)31(52)41-21(6-7-26(45)46)29(50)42-23(9-18-13-37-14-38-18)32(53)43-24(12-27(47)48)30(51)40-17-4-5-19-20(33(34,35)36)11-28(49)54-25(19)10-17/h4-5,10-11,13-15,21-24H,6-9,12H2,1-3H3,(H,37,38)(H,39,44)(H,40,51)(H,41,52)(H,42,50)(H,43,53)(H,45,46)(H,47,48)/t21-,22-,23-,24-/m0/s1
InChI key	HULKIXRFKRCRHD-ZJZGAYNASA-N
Quality Level	200
SMILES string	CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(O)=O)C(=O)Nc2ccc3c(OC(=O)C=C3C(F)(F)F)c2
solubility	DMSO/DMF: 20 mM
storage temp.	−20°C

Amino Acid Sequence:	NAc-Leu-Glu-His-Asp-AFC
Application:	N-Acetyl-Leu-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin has been used to assay caspase 9 activity using a substrate-based fluorimetric detection assay
General description:	Amino acid derivatives of 7-amido-4-trifluoromethylcoumarin (AFC) are blue in fluorescence microscopy.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352209

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