Acetazolamide
SIGMA/A6011 - ≥99%, powder
Synonym: 5-
CAS Number: 59-66-5
Empirical Formula (Hill Notation): C4H6N4O3S2
Molecular Weight: 222.25
EC Number: 200-440-5
MDL Number: MFCD00003105
Linear Formula: C4H6N4O3S2
Product Type: Chemical
| assay | ≥99% |
| biological source | synthetic |
| form | powder |
| InChI | 1S/C4H6N4O3S2/c1-2(9)6-3- |
| InChI key | BZKPWHYZMXOIDC-UHFFFAOYSA |
| mp | 258-259 °C |
| pKa | 7.2 |
| Quality Level | 200  |
| SMILES string | CC(=O)Nc1nnc(s1)S(N)(=O)= |
| solubility | 1 M NH4OH: 50 mg/mL |
| DMSO: soluble | |
| methanol and ethanol: slightly soluble |
| Application: | Acetazolamide has been used: • to study its protective effect on steatotic liver grafts against cold ischemia reperfusion injury{49) • to determine its ability to bind isolated porcine retinal pigment epithelium (RPE) melanin by cassette dosing and rapid equilibrium dialysis inserts • to validate the in vitro gastrulation model of P19C5 stem cells for developmental toxicity screening assays • to study its inhibitory effect on melanogenesis through enzyme kinetic, in vitro, in vivo and in silico analyses in zebrafish and in A375 human melanoma cells |
| Application: | Carbonic anhydrase inhibitor; increases cerebral blood flow. |
| Biochem/physiol Actions: | Acetazolamide is a member of sulfonamide drug family. It as an ability to inhibit the activity of carbonic anhydrase. It rapidly increases cerebral blood flow (CBF) and is used as an investigative tool in CBF studies. Acetazolamide acts as a therapeutic agent for epilepsy, glaucoma and pseudotumor cerebri. |
| Biochem/physiol Actions: | Inhibits water permeability of membranes by interacting with aquaporins |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 |
| Precautionary statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% |
| mp | 258-259 °C |
| UNSPSC | 12352202 |