Calpain Inhibitor II
SIGMA/A6060 - powder
Synonym: N-Acetyl-L-leucyl-L-leucyl-L-methioninal
CAS Number: 110115-07-6
Empirical Formula (Hill Notation): C19H35N3O4S
Molecular Weight: 401.56
MDL Number: MFCD00065506
Linear Formula: C19H35N3O4S
Product Type: Chemical
| assay | ≥95% (HPLC) |
| color | white |
| form | powder |
| InChI | 1S/C19H35N3O4S/c1-12(2)9- |
| InChI key | RJWLAIMXRBDUMH-ULQDDVLXSA |
| Quality Level | 100  |
| SMILES string | [H]C(=O)[C@H](CCSC)NC(=O) |
| solubility | ethanol: 20 mg/mL |
| storage temp. | −20°C |
| Application: | Calpain Inhibitor II has been used in western blotting. It has also been used to study the mechanism of Spy1A (a cyclin-like protein) degradation during cell cycle. |
| Application: | Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons. |
| Biochem/physiol Actions: | Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation. |
| Other Notes: | Formerly CAS# 136632-32-1 |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |