Calpain Inhibitor I
SIGMA/A6185 - ≥97% (TLC), powder
Synonym: ALLN; Ac-LLnL-CHO; MG-101; N-Acetyl-L-leucyl-L-leucyl-L-norleucinal; N-
CAS Number: 110044-82-1
Empirical Formula (Hill Notation): C20H37N3O4
Molecular Weight: 383.53
MDL Number: MFCD00065505
Linear Formula: C20H37N3O4
Product Type: Chemical
assay | ≥97% (TLC) |
biological source | synthetic (organic) |
color | white |
form | powder |
InChI | 1S/C20H37N3O4/c1-7-8-9-16 |
InChI key | FMYKJLXRRQTBOR-BZSNNMDCSA |
Quality Level | 200 |
SMILES string | [H]C(=O)[C@H](CCCC)NC(=O) |
solubility | DMSO: soluble |
ethanol: soluble | |
storage temp. | −20°C |
Application: | Calpain Inhibitor I have been used: • as a component of protease inhibitor cocktail for gel shift analysis • for treating HeLa cell cultures • for inhibition of 26 S proteasome in 26 S proteasome inhibition assays |
Biochem/physiol Actions: | Calpain Inhibitor I inhibits tumor necrosis factor-induced (TNF-induced) cleavage of Poly (ADP-ribose) polymerase (PARP) and calpastatin in apoptosis. It also inhibits oxygen/glucose deprivation (OGD) induced cleavage of caspase-12 and Bcl-xL.. |
Biochem/physiol Actions: | Can initiate apoptosis in HL-60 cells but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes. Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase. Blocks induction of nitric oxide synthase by LPS in macrophages. |
Packaging: | 5, 25 mg in serum bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥97% (TLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |