Calpain Inhibitor I
SIGMA/A6185 - ≥97% (TLC), powder
Synonym: ALLN; Ac-LLnL-CHO; MG-101; N-Acetyl-L-leucyl-L-leucyl-L-norleucinal; N-
CAS Number: 110044-82-1
Empirical Formula (Hill Notation): C20H37N3O4
Molecular Weight: 383.53
MDL Number: MFCD00065505
Linear Formula: C20H37N3O4
Product Type: Chemical
| assay | ≥97% (TLC) |
| biological source | synthetic (organic) |
| color | white |
| form | powder |
| InChI | 1S/C20H37N3O4/c1-7-8-9-16 |
| InChI key | FMYKJLXRRQTBOR-BZSNNMDCSA |
| Quality Level | 200  |
| SMILES string | [H]C(=O)[C@H](CCCC)NC(=O) |
| solubility | DMSO: soluble |
| ethanol: soluble | |
| storage temp. | −20°C |
| Application: | Calpain Inhibitor I have been used: • as a component of protease inhibitor cocktail for gel shift analysis • for treating HeLa cell cultures • for inhibition of 26 S proteasome in 26 S proteasome inhibition assays |
| Biochem/physiol Actions: | Calpain Inhibitor I inhibits tumor necrosis factor-induced (TNF-induced) cleavage of Poly (ADP-ribose) polymerase (PARP) and calpastatin in apoptosis. It also inhibits oxygen/glucose deprivation (OGD) induced cleavage of caspase-12 and Bcl-xL.. |
| Biochem/physiol Actions: | Can initiate apoptosis in HL-60 cells but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes. Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase. Blocks induction of nitric oxide synthase by LPS in macrophages. |
| Packaging: | 5, 25 mg in serum bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (TLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |