3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione hydrochloride

SIGMA/A6355 - powder, ≥98% (HPLC)

Synonym: Erk Inhibitor

CAS Number: 294675-79-9 (free base)
Empirical Formula (Hill Notation): C₁₄H₁₆N₂O₃S · HCl
Molecular Weight: 328.81
MDL Number: MFCD09038681
Linear Formula: C₁₄H₁₆N₂O₃S · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-A6355-5MG	5 mg	$134.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	off-white
form	powder
InChI	1S/C14H16N2O3S.ClH/c1-2-19-11-5-3-10(4-6-11)9-12-13(17)16(8-7-15)14(18)20-12;/h3-6,9H,2,7-8,15H2,1H3;1H/b12-9+;
InChI key	PQVLWVGMXJPJLG-NBYYMMLRSA-N
Quality Level	100
SMILES string	Cl[H].CCOc1ccc(cc1)C=C2SC(=O)N(CCN)C2=O
solubility	DMSO: ≥4 mg/mL
storage condition	desiccated
	under inert gas
storage temp.	2-8°C

Application:	3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione is an extracellular signal-regulated kinase (ERK) docking domain inhibitor. ERK inhibitors have been used to study traumatic brain injuries.
Biochem/physiol Actions:	3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione is extracellular signal-regulated kinase (ERK) docking domain inhibitor. Inhibits ERK binding rather then ERK activity at the ATP domain. IC₅₀ = 25 μM in HeLa, A549, and SUM-159 tumor cells. Currently, no specific inhibitors of the ERK proteins exist. Preferentially binds to ERK2 with a Kd of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1, but exhibits little effect on ERK1/2 phosphorylation by MEK1/2.
Features and Benefits:	This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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