[Asn1, Val5]-Angiotensin II
SIGMA/A6402 - ≥97% (HPLC)
CAS Number: 20071-00-5
Empirical Formula (Hill Notation): C49H70N14O11
Molecular Weight: 1031.17
MDL Number: MFCD00167643
Linear Formula: C49H70N14O11
Product Type: Chemical
assay | ≥97% (HPLC) |
form | powder |
InChI | 1S/C49H70N14O11/c1-26(2)3 |
InChI key | JYPVVOOBQVVUQV-CGHBYZBKSA |
Quality Level | 200 |
SMILES string | CC(C)[C@H](NC(=O)[C@H](CC |
storage temp. | −20°C |
Amino Acid Sequence: | Asn-Arg-Val-Tyr-Val-His-P |
Application: | [Asn1, Val5]-Angiotensin II has been used: • to study the effects of ACTH, serotonin, Ang II, carbachol and elevated [K+] on catecholamine and serotonin release • to induce cyclophilin D (CypD)–dependent mitochondrial vascular superoxide (O2. - ) production in hypertension • to increase the homocysteine-induced ER stress-inducible, ubiquitin-like domain member 1 (HERPUD1) protein level in HeLa cells |
Biochem/physiol Actions: | Angiotensin II functions as a vasoconstrictor and controls cardiovascular function. It maintains water-sodium homeostasis, modulates cellular proliferation and vascular remodelling of renin-angiotensin system. Angiotensin II has inflammatory effects. |
Biochem/physiol Actions: | Synthetic angiotensin agonist that is involved in the regulation of blood pressure, water consumption, and hydromineral balance in fish. |
General description: | Angiotensin II is a renin-angiotensin system (RAS) effector molecule, which binds to angiotensin II type-1 (AT1R) and angiotensin II type-2 (AT2R) receptors. The gene is located on human chromosome 3q24. Angiotensin II is mainly expressed in vessel walls, lung and kidney. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥97% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352209 |