Aflatoxin B1 from Aspergillus flavus
SIGMA/A6636 - from Aspergillus flavus
CAS Number: 1162-65-8
Empirical Formula (Hill Notation): C17H12O6
Molecular Weight: 312.27
EC Number: 214-603-3
MDL Number: MFCD00869647
Linear Formula: C17H12O6
Product Type: Chemical
12 Principles of Green Chemistry: Principle 1—Waste Prevention. This product has a smaller environmental footprint through reduction of waste in the manufacturing process.
12 Principles of Green Chemistry: Principle 4—Designing Safer Chemicals
Chemical products should be designed to affect their desired function while minimizing their toxicity.
Chemical products should be designed to affect their desired function while minimizing their toxicity.
| assay | ≥98.0% (HPLC) |
| biological source | Aspergillus flavus |
| form | powder |
| greener alternative category | Re-engineered  , |
| greener alternative product characteristics | Waste Prevention Designing Safer Chemicals Design for Energy Efficiency Learn more about the Principles of Green Chemistry . |
| greener alternative product score | old score: 51 new score: 42 Find out more about DOZN™ Scoring |
| InChI | 1S/C17H12O6/c1-20-10-6-11 |
| InChI key | OQIQSTLJSLGHID-WNWIJWBNSA |
| Quality Level | 300 |
| SMILES string | COc1cc2OC3OC=CC3c2c4OC(=O |
| storage temp. | 2-8°C |
| sustainability | Greener Alternative Product |
| Application: | Aflatoxin B1 is a carcinogenic compound that induces transversion of G to T at codon 249 of the p53 tumor suppressor gene. Aflatoxin B1 may be used as an internal standard when testing for aflatoxin contamination in food products. |
| Biochem/physiol Actions: | Aflatoxin B1 is a carcinogenic compound produced by Aspergillus flavus, a common soil fungus, that induces transversion of G to T at codon 249 of the p53 tumor suppressor gene. Aflatoxin B1 is a food contaminant and a hepatocarcinogen. Aflatoxin is biotransformed to genotoxic intermediates by P450 Phase I enzymes, mainly CYP3A4 via aflatoxin B1 3-hydroxylation. Detoxification depends on Phase II enzymes, such as Glutathione S-Transferase and AFB(1)-aldehyde reductase (AFAR). Aflatoxin B1 is a CYP1A2, CYP2A6, CYP2D6, and CYP3A family substrate. |
| General description: | We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Designing Safer Chemicals” and “Design for Energy Efficiency”. Click here to view its DOZN scorecard. |
| Warning: | Possibly carcinogenic. |
| Symbol |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H300 + H310 + H330 - H340 - H350 - H361 |
| Precautionary statements | P201 - P202 - P260 - P280 - P302 + P352 + P310 - P304 + P340 + P310 |
| Hazard Codes | T+ |
| Risk Statements | 45-46-26/27/28 |
| Safety Statements | 53-28-36/37-45 |
| RIDADR | UN 3462 6.1 / PGI |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98.0% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |