ω-Agatoxin IVA
SIGMA/A6719 - ≥90% (HPLC)
Synonym: SNX 290
CAS Number: 145017-83-0
Empirical Formula (Hill Notation): C217H360N68O60S10
Molecular Weight: 5202.25
MDL Number: MFCD00165055
Linear Formula: C217H360N68O60S10
Product Type: Chemical
| application(s) | metabolomics vitamins, nutraceuticals, and natural products |
| assay | ≥90% (HPLC) |
| form | powder |
| Quality Level | 200  |
| storage temp. | −20°C |
| Amino Acid Sequence: | Lys-Lys-Lys-Cys-Ile-Ala-L |
| Application: | ω-Agatoxin IVA has been used in the manipulation of calcium influx. It has also been used in the study to characterize the spontaneous and evoked activity from murine ventral horn cultures on microelectrode arrays. |
| Biochem/physiol Actions: | Mutations in the CACNA1A (calcium voltage-gated channel subunit alpha1 A) gene is responsible for episodic ataxia 2, familial hemiplegic migraine type 1 (FHM1) and spinocerebellar ataxia type 6 (SCA6). |
| Biochem/physiol Actions: | Toxin found in the venom of the funnel web spider, Agelenopsis aptera. Potent, selective blocker of mammalian P-type voltage-dependent calcium channels. |
| Features and Benefits: | This compound was developed by Pfizer . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: | CACNA1A (calcium voltage-gated channel subunit alpha1 A) gene codes for the α1 subunit of neuronal CaV2.1 (P/Q-type) voltage-gated calcium channels. It is expressed throughout the central nervous system (CNS). CACNA1A gene is located on human chromosome 19p13. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |