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Methotrexate hydrate

SIGMA/A6770 - ≥98% (HPLC), powder

Synonym: 4-Amino-10-methylfolic acid hydrate; L-4-Amino-N10-methylpteroylglutamic acid hydrate; L-Amethopterin hydrate; Antifolan hydrate; MTX hydrate; Methylaminopterin hydrate

CAS Number: 133073-73-1
Empirical Formula (Hill Notation): C20H22N8O5 · xH2O
Molecular Weight: 454.44 (anhydrous basis)
MDL Number: MFCD00150847
Linear Formula: C20H22N8O5 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A6770-10MG 10 mg
 $70.40
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45-A6770-25MG 25 mg
 $82.30
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45-A6770-100MG 100 mg
 $183.00
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45-A6770-500MG 500 mg
 $865.00
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45-A6770-1G 1 g
 $1510.00
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assay ≥98% (HPLC)
biological source synthetic (organic)
color , yellow to very dark yellow to very dark orange
form powder
InChI 1S/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);1H2/t13-;/m0./s1
InChI key FPJYMUQSRFJSEW-ZOWNYOTGSA-N
mp 185-204  °C
Quality Level 200 
SMILES string [H]O[H].CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O
solubility H2O: insoluble
storage temp. −20°C
Application: Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems.
Application: Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.
Application: Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Purity ≥98% (HPLC)
mp 185-204  °C
Storage Temp. −20°C
UNSPSC 12352202

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