L-Asparagine monohydrate

SIGMA/A7094 - from non-animal source, BioReagent, suitable for cell culture, ≥98.0%

Synonym: Asparagine monohydrate; (S)-(+)-2-Aminosuccinamic acid; (S)-2-Aminosuccinic acid 4-amide; L-Aspartic acid 4-amide

CAS Number: 5794-13-8
Empirical Formula (Hill Notation): C₄H₈N₂O₃ · H₂O
Molecular Weight: 150.13
EC Number: 200-735-9
MDL Number: MFCD00151038
Linear Formula: NH₂COCH₂CH(NH₂)COOH · H₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A7094-25G	25 g	$80.70 1/EA	Add To Favorites
45-A7094-100G	100 g	$133.00 1/EA	Add To Favorites
45-A7094-1KG	1 kg	$801.00 1/EA	Add To Favorites

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This image depicts SKU: A7094-100G

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98.0%
biological source	non-animal source
cation traces	<0.1% (Ammonia (NH3))
	Fe: ≤10 ppm
	heavy metals (as Pb): ≤10 ppm
color	white
form	powder
functional group	amide
	amine
	carboxylic acid
impurities	endotoxin, tested
InChI	1S/C4H8N2O3.H2O/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H2,6,7)(H,8,9);1H2/t2-;/m0./s1
InChI key	RBMGJIZCEWRQES-DKWTVANSSA-N
mp	233-235 °C (lit.)
optical activity	[α]20/D 33.0 to 36.3 °, c = 10 in 6 M HCl
product line	BioReagent
Quality Level	300
SMILES string	[H]O[H].N[C@@H](CC(N)=O)C(O)=O
solubility	H₂O: 20 mg/mL
storage temp.	room temp
technique(s)	cell culture \| mammalian: suitable

Application:	L-Asparagine is used in cell culture media and is a component of MEM non-essential amino acids solution. L-Asparagine has been shown to enhance ornithine decarboxylase activity in cultured human colon adenocarcinoma Caco-2 cells and in cultured IEC-6 intestinal epithelial cells. Spore germination in Bacillus subtilis has been increased in the presence of L-asparagine. L-Asparagine, a proteinogenic amino acid, from non-animal source is used in biomanufacturing cell culture systems for the production of therapeutic recombinant proteins and monoclonal antibodies. It has also been used as a component of LHC basal media for the culture of human airway epithelial cells.
Biochem/physiol Actions:	The amino acid L-asparagine is a structural analog of L-aspartic acid, where the side chain of the carboxylic acid moiety is amidated to give a terminal amine group. This renders L-asparagine neutral at physiological pH. The amide group of asparagine is derived from glutamine, in the reaction of aspartate and glutamine in the presence of ATP to yield asparagine and glutamate. In vivo, asparagine is hydrolyzed to aspartate and NH4⁺ by asparaginase. Asparagine is also an important amino acid in glycopeptide bonds, via N-glycosyl linkages to the sugar rings.
Features and Benefits:	• Suitable for Cell Culture and Biochemical research • High-quality compound suitable for multiple research applications
General description:	L-Asparagine is a naturally occurring amino acid found in various proteins. It is used in laboratory research for various applications, including cell culture, protein biochemistry, and nitrogen metabolism studies. Its solubility in water and role as a source of asparagine make it a versatile tool for investigating biological processes and chemical synthesis. Further, L-Asparagine residues in proteins can be crucial for protein stability, folding, and interactions.
Other Notes:	For additional information on our range of Biochemicals , please complete this form .
Packaging:	1 kg in poly bottle
Packaging:	25, 100 g in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 1
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98.0%
mp	233-235 °C (lit.)
Storage Temp.	room temp
UNSPSC	12352209

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