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Azelnidipine

SIGMA/A7106 - ≥98% (HPLC), powder

Synonym: 2-Amino-1,4-dihydro-6-methyl-4-(3 nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester; CS-905; RS-9054

CAS Number: 123524-52-7
Empirical Formula (Hill Notation): C33H34N4O6
Molecular Weight: 582.65
MDL Number: MFCD00865803
Linear Formula: C33H34N4O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A7106-10MG 10 mg
 $180.00
1/EA		 Add To Favorites
45-A7106-50MG 50 mg
 $811.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
form powder
InChI 1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3
InChI key ZKFQEACEUNWPMT-UHFFFAOYSA-N
originator Daiichi-Sankyo
Quality Level 100 
SMILES string CC(C)OC(=O)C1=C(C)NC(N)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC3CN(C3)C(c4ccccc4)c5ccccc5
solubility DMSO: >10 mg/mL
storage temp. room temp
Application: Azelnidipine is a novel dihydropyridine derivative, a L-type calcium channel blocker, and an antihypertensive. Acute administration of azelnidipine prevents a sudden drop of cardiac function after acute stress. Azelnidipine may have a protective role in inflammation associated with atherosclerosis.
Biochem/physiol Actions: Azelnidipine is a L-type calcium channel blocker; antihypertensive.
Biochem/physiol Actions: Azelnidipine, a novel dihydropyridine derivative, is a L-type calcium channel blocker and antihypertensive. Unlike other L-type calcium channel blockers, azelnidipine causes minimal stimulation of the sympathetic nervous system despite its significant depressor effect. Azelnidipine may have a protective role in inflammation in atherosclerosis.
Features and Benefits: This compound is featured on the Calcium Channels  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Daiichi-Sankyo . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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