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Agmatine sulfate salt

SIGMA/A7127 - ≥97%, powder

Synonym: 1-Amino-4-guanidinobutane sulfate salt; 4-Guanidinobutylamine sulfate salt; N-(4-Aminobutyl)guanidine sulfate salt

CAS Number: 2482-00-0
Empirical Formula (Hill Notation): C5H14N4 · H2SO4
Molecular Weight: 228.27
EC Number: 219-617-3
MDL Number: MFCD00013109
Linear Formula: H2N(CH2)4NHC(=NH)NH2·H2SO4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A7127-1G 1 g
 $98.10
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45-A7127-5G 5 g
 $358.00
1/EA		 Add To Favorites

 

assay ≥97%
color white to off-white
form powder
InChI 1S/C5H14N4.H2O4S/c6-3-1-2-4-9-5(7)8;1-5(2,3)4/h1-4,6H2,(H4,7,8,9);(H2,1,2,3,4)
InChI key PTAYFGHRDOMJGC-UHFFFAOYSA-N
mp 234-238 °C (lit.)
Quality Level 100 
SMILES string OS(O)(=O)=O.NCCCCNC(N)=N
solubility ethanol: insoluble
  H2O: 50 mg/mL
Application: Agmatine sulfate salt has been used:• to study its effects on nod-like receptor protein 3 (NLRP3) inflammasome activation and cytokine responses in sub-chronic restraint stress rat models
• as an N-methyl-D-aspartate (NMDA) receptor blocker to study its therapeutic effects on autistic behaviors in the valproic acid-induced animal model of autism
• as a standard to determine the bioactive amines in vegetables by high-performance liquid chromatography (HPLC)
Biochem/physiol Actions: Agmatine is a decarboxylated arginine that is present ubiquitously in all living organisms. It is found in food sources such as plant source food and animal products. It exhibits cryoprotective effects against several body functions such as nephroprotection, neuroprotection, gastroprotection, and cardioprotection. Agmatine also exhibits therapeutic effects against neurotrauma, neuropathic pain, diabetes, neurodegenerative diseases, and psychiatric diseases. It is involved in blocking many ionic channels such as ATP-sensitive K+ channels and voltage-gated Ca2+ channels. Agmatine modulates nitric oxide production and inhibits matrix metalloproteases.
Biochem/physiol Actions: Putative endogenous neurotransmitter at imidazoline receptors; displaces clonidine at α2-adrenergic and at imidazoline receptors; blocks NMDA-activated ion channels in hippocampal neurons.
Packaging: 1, 5 g in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97%
mp 234-238 °C (lit.)
UNSPSC 12352200

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