AP-18
SIGMA/A7232 - ≥98% (HPLC), solid
Synonym: 4-
CAS Number: 55224-94-7
Empirical Formula (Hill Notation): C11H12ClNO
Molecular Weight: 209.67
MDL Number: MFCD00102250
Linear Formula: C11H12ClNO
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to off-white |
| form | solid |
| InChI | 1S/C11H12ClNO/c1-8(9(2)13 |
| InChI key | MHTJEUOFLVQMCL-NJHPPEEMSA |
| Quality Level | 100  |
| SMILES string | CC(=C/c1ccc(Cl)cc1)C(C)= |
| solubility | DMSO: >10 mg/mL |
| storage temp. | 2-8°C |
| Application: | AP-18 is a selective TRPA1 channel blocker. AP-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. AP-18 reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. AP-18 reverses CFA-induced mechanical hyperalgesia in mice |
| Biochem/physiol Actions: | AP-18 is a selective TRPA1 channel blocker. |
| Biochem/physiol Actions: | AP-18 is a selective TRPA1 channel blocker. Transient receptor potential A1 (TRPA1) plays a central role for chemical sensing in the pain pathway. AP-18 is a novel TRPA1 channel blocker. It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs. TRPV11. AP-18 reverses CFA-induced mechanical hyperalgesia in mice. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264 - P270 - P301 + P312 - P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |