(−)-Norepinephrine
SIGMA/A7257 - ≥98%, crystalline
Synonym: (R)
CAS Number: 51-41-2
Empirical Formula (Hill Notation): C8H11NO3
Molecular Weight: 169.18
EC Number: 200-096-6
MDL Number: MFCD00025592
Linear Formula: C8H11NO3
Product Type: Chemical
assay | ≥98% |
color | off-white to tan |
form | crystalline |
InChI | 1S/C8H11NO3/c9-4-8(12)5-1 |
InChI key | SFLSHLFXELFNJZ-QMMMGPOBSA |
Quality Level | 200 |
SMILES string | NC[C@H](O)c1ccc(O)c(O)c1 |
storage temp. | −20°C |
Application: | (−)-Norepinephrine has been used: • as anαand β-AR agonist to stimulate mouse organoids to study the pathways that are activated upon intestinal epithelial adrenergic receptor (AR) stimulation, • to measure the monoamine levels in various limbic regions of mouse brains by high-performance liquid chromatography (HPLC) coupled with an electrochemical equipped with an auto-sampler, • as a dispersal agent in biofilm dispersion assay to study its effects on the dispersal of Mannheimia haemolytica biofilms |
Features and Benefits: | This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
General description: | Norepinephrine is a neurotransmitter found in both the peripheral and central nervous systems. It triggers effects associated with the ′fight or flight′ response and is mediated by the family of adrenergic receptors. Structurally, it is a catecholamine due to the presence of the catechol moiety (consisting of two hydroxyl groups on a benzene ring) and an amine (NH2) group. Norepinephrine exhibits pharmacologic effects on α1 and β1 adrenoceptors. It does not elevate heart rate. The primary advantage of norepinephrine is to improve organ perfusion by increasing vascular tone. Compared to dopamine, norepinephrine is more effective at achieving targeted endpoints, less metabolically active than epinephrine, and reduces serum lactate levels. Moreover, it notably enhances renal perfusion and splanchnic blood flow in sepsis, especially when used alongside dobutamine. Norepinephrine is used in the treatment of hypotension, depression, schizophrenia, and attention deficit/hyperactivity disorders. |
Packaging: | 1, 5 g in poly bottle |
Packaging: | 500 mg in poly bottle |
Symbol | GHS06 |
Signal word | Danger |
Hazard statements | H300 + H310 + H330 |
Precautionary statements | P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310 |
Hazard Codes | T+ |
Risk Statements | 26/27/28 |
Safety Statements | 28-36/37-45 |
RIDADR | UN 2811 6.1 / PGII |
WGK Germany | WGK 3 |
Purity | ≥98% |
Storage Temp. | −20°C |
UNSPSC | 12352200 |