L-Ascorbic acid
SIGMA/A7506 - reagent grade, crystalline
Synonym: L-Threoascorbic acid; Antiscorbutic factor; Vitamin C
CAS Number: 50-81-7
Empirical Formula (Hill Notation): C6H8O6
Molecular Weight: 176.12
EC Number: 200-066-2
MDL Number: MFCD00064328
Linear Formula: C6H8O6
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: A7506-100G
This image depicts SKU: A7506-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: A7506-500G
This image depicts SKU: A7506-500G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: A7506-1KG
This image depicts SKU: A7506-1KG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: A7506-25G
This image depicts SKU: A7506-25G
| assay | ≥98% ( with iodine, titration) |
| biological source | synthetic |
| color | white to slightly yellow |
| form | crystalline |
| grade | reagent grade |
| InChI | 1S/C6H8O6/c7-1-2(8)5-3(9) |
| InChI key | CIWBSHSKHKDKBQ-JLAZNSOCSA |
| mp | 190-194 °C (dec.) |
| pH | 1.0-2.5 (25 °C, 176 g/L in water) |
| Quality Level | 200  |
| SMILES string | OC([C@]([C@@H](O)CO)([H]) |
| solubility | water: soluble 50 mg/mL |
| storage temp. | room temp |
| technique(s) | cell culture | stem cell: suitable |
| HPLC: suitable |
| Application: | L-Ascorbic acid has been used: • as a chondrogenic medium component for culturing bone-derived mesenchymal stem cells (BMSCs)(149) • as a reference standard in high-performance liquid chromatography system (HPLC)(150) • to test its effect on human gastric cancer GES-1 and AGS cells(151) |
| Biochem/physiol Actions: | Ascorbic Acid, also known as Vitamin C, is a six-carbon lactone produced by plants and some animal species but not by humans and other primates. Ascorbic acid functions as an enzymatic cofactor for multiple enzymes, serving as an electron donor for monooxygenases and dioxygenases. Ascorbic acid also functions as a powerful antioxidant, particularly in regards to reactive oxygen species. |
| Biochem/physiol Actions: | L-Ascorbic acid deficiency is associated with lack of L-gulono-1,4-lactone oxidase (GLO) enzyme. It elicits antioxidant functionality and gets oxidized to dehydroascorbate via ascorbyl radical intermediate. L-Ascorbic acid is essential for maintaining the redox balance. It is a cofactor for dopamine-β-hydroxylase and favors T cell proliferation, protects immune system and provides relief in common cold. |
| Caution: | May darken in storage. |
| General description: | L-Ascorbic acid biosynthetic pathway varies in plants, animals and fungi. It is synthesized from L-gulono-1,4-lactone by the action of enzyme L-gulono-1,4-lactone oxidase (GLO). |
| Packaging: | 1 kg in poly bottle |
| Packaging: | 25, 100, 500 g in poly bottle |
| Packaging: | 5 kg in poly drum |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Purity | ≥98% ( with iodine, titration) |
| mp | 190-194 °C (dec.) |
| Storage Temp. | room temp |
| UNSPSC | 12352209 |