A-331440 dihydrochloride
SIGMA/A7730 - ≥98% (HPLC), solid
Synonym: 4’-
CAS Number: 392338-13-5 (free base)
Empirical Formula (Hill Notation): C22H27N3O · 2HCl
Molecular Weight: 422.39
MDL Number: MFCD08705336
Linear Formula: C22H27N3O · 2HCl
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to off-white |
| form | solid |
| InChI | 1S/C22H27N3O.2ClH/c1-24(2 |
| InChI key | XFPYVTSGYYMTFS-GHVWMZMZSA |
| originator | Abbott |
| Quality Level | 100  |
| SMILES string | CN([C@H]1CN(CCCOC2=CC=C(C |
| solubility | H2O: ≥10 mg/mL |
| storage condition | desiccated |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | A-331440 dihydrochloride is a non-imidazole H3 histamine receptor antagonist. Presynaptic histamine H(3) receptors regulate release of histamine and other neurotransmitters, and histamine H(3) receptor antagonists enhance neurotransmitter release. A-331440 is a histamine H(3) receptor antagonist, which binds potently and selectively to both human and rat histamine H(3) receptors (K(i)=25 nM). Mice on a high-fat diet (45 kcal % lard) prior to 28-day oral b.i.d. dosing for measurement of obesity-related parameters. A-331440 administered at 0.5 mg/kg had no significant effect on weight, whereas 5 mg/kg decreased weight comparably to dexfenfluramine (10 mg/kg). A-331440 administered at 15 mg/kg reduced weight to a level comparable to mice on the low-fat diet. The two higher doses reduced body fat and the highest dose also normalized an insulin tolerance test. Both data shows that the histamine H(3) receptor antagonist, A-331440, has potential as an antiobesity agent. |
| Features and Benefits: | This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by Abbott . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |