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Asenapine maleate

SIGMA/A7861 - ≥98% (HPLC)

Synonym: (3aRS,12bRS)-5-Chloro-2-methyl-2,3,3a,12btetrahydro-1Hdibenzo[2,3:6,7]oxepino[4,5-c]pyrrole (2Z)-2-butenedioate; Org 5222; trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole maleate

CAS Number: 85650-56-2
Empirical Formula (Hill Notation): C17H16ClNO ·C4H4O4
Molecular Weight: 401.84
EC Number: 288-064-8
MDL Number: MFCD00900588
Linear Formula: C17H16ClNO ·C4H4O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A7861-10MG 10 mg
 $90.50
1/EA		 Add To Favorites
45-A7861-50MG 50 mg
 $359.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts A7861-10MG.

 

assay ≥98% (HPLC)
color white to off-white
form powder
InChI 1S/C17H16ClNO.C4H4O4/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19;5-3(6)1-2-4(7)8/h2-8,14-15H,9-10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15-;/m1./s1
InChI key GMDCDXMAFMEDAG-CHHFXETESA-N
originator Merck & Co., Inc., Kenilworth, NJ, U.S.
Quality Level 100 
SMILES string OC(=O)C=C/C(O)=O.CN1C[C@H]2[C@H](C1)c3cc(Cl)ccc3Oc4ccccc24
solubility H2O: ≥10 mg/mL
storage temp. 2-8°C
Application: Asenapine maleate has been used as a stressor in studying the Fos expression in forebrain structures of rat models.
Application: Asenapine maleate is a serotonin 5-HT and dopamine D2 receptor antagonist. Asenapine maleate can be used to treat schizophrenia and bipolar mania.
Biochem/physiol Actions: Asenapine maleate is a 5-HT receptor antagonist (5-HT1A,1B, 5-HT2A, 2B, 2C, 5-HT5A, 5-HT6 and 5-HT7), a D2 antagonist, and an antipsychotic.
Features and Benefits: This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S. . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description: Asenapine maleate acts as an antimanic. It belongs to the family of dibenzoxepinopyrrolidines. Asenapine is considered to be a weak inhibitor of cytochrome P450 2D6 (CYP2D6). It increases the level of dopamine, norepinephrine and acetylcholine in brain.
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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