Synonym: (3aRS,12bRS)-5-Chloro-2-methyl-2,3,3a,12btetrahydro-1Hdibenzo[2,3:6,7]oxepino[4,5-c]pyrrole (2Z)-2-butenedioate; Org 5222; trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole maleate
CAS Number: 85650-56-2
Empirical Formula (Hill Notation): C17H16ClNO ·C4H4O4
Molecular Weight: 401.84
EC Number: 288-064-8
MDL Number: MFCD00900588
Linear Formula: C17H16ClNO ·C4H4O4
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to off-white |
| form |
powder |
| InChI |
1S/C17H16ClNO.C4H4O4/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19;5-3(6)1-2-4(7)8/h2-8,14-15H,9-10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15-;/m1./s1 |
| InChI key |
GMDCDXMAFMEDAG-CHHFXETESA-N |
| originator |
Merck & Co., Inc., Kenilworth, NJ, U.S. |
| Quality Level |
100  |
| SMILES string |
OC(=O)C=C/C(O)=O.CN1C[C@H]2[C@H](C1)c3cc(Cl)ccc3Oc4ccccc24 |
| solubility |
H2O: ≥10 mg/mL |
| storage temp. |
2-8°C |
| Application: |
Asenapine maleate has been used as a stressor in studying the Fos expression in forebrain structures of rat models. |
| Application: |
Asenapine maleate is a serotonin 5-HT and dopamine D2 receptor antagonist. Asenapine maleate can be used to treat schizophrenia and bipolar mania. |
| Biochem/physiol Actions: |
Asenapine maleate is a 5-HT receptor antagonist (5-HT1A,1B, 5-HT2A, 2B, 2C, 5-HT5A, 5-HT6 and 5-HT7), a D2 antagonist, and an antipsychotic. |
| Features and Benefits: |
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S. . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: |
Asenapine maleate acts as an antimanic. It belongs to the family of dibenzoxepinopyrrolidines. Asenapine is considered to be a weak inhibitor of cytochrome P450 2D6 (CYP2D6). It increases the level of dopamine, norepinephrine and acetylcholine in brain. |
| Packaging: |
10, 50 mg in glass bottle |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
GHS06,GHS09