2-Amino-2-norbornanecarboxylic acid

SIGMA/A7902 - amino acid transport inhibitor

Synonym: BCH; 2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid

CAS Number: 20448-79-7
Empirical Formula (Hill Notation): C₈H₁₃NO₂
Molecular Weight: 155.19
MDL Number: MFCD00167580
Linear Formula: C₈H₁₃NO₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A7902-100MG	100 mg	$132.00 1/EA	Add To Favorites
45-A7902-250MG	250 mg	$249.00 1/EA	Add To Favorites
45-A7902-1G	1 g	$748.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

color	white to off-white
form	powder
InChI	1S/C8H13NO2/c9-8(7(10)11)4-5-1-2-6(8)3-5/h5-6H,1-4,9H2,(H,10,11)/t5-,6+,8?/m1/s1
InChI key	MPUVBVXDFRDIPT-RSHNMJPRSA-N
mp	>300 °C (lit.)
Quality Level	100
SMILES string	NC1(C[C@@H]2CC[C@H]1C2)C(O)=O
technique(s)	ligand binding assay: suitable

Analysis Note:	Mixture of exo- and endo-isomers.
Application:	Thyroid Hormone Transporters in a Human Placental Cell Model.: This study investigates the role of 2-Amino-2-norbornanecarboxylic acid in the transport of thyroid hormones in placental cells, offering insights that could improve understanding of fetal development and maternal health (Chen et al., 2022 ). Metabolic adaptations to hypoxia in the neonatal mouse forebrain can occur independently of the transporters SLC7A5 and SLC3A2.: Research explores how 2-Amino-2-norbornanecarboxylic acid affects metabolic responses to hypoxia in neonatal brain development, providing a foundation for future studies on brain health and neurodevelopment (Fitzgerald et al., 2021 ). Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis.: This article assesses the potential of 2-Amino-2-norbornanecarboxylic acid as a selective inhibitor that could lead to new treatments for cancer while preserving critical brain functions (Markowicz-Piasecka et al., 2020 ). Regulation of Melanogenesis by the Amino Acid Transporter SLC7A5.: Research demonstrates the utility of 2-Amino-2-norbornanecarboxylic acid in regulating skin pigmentation processes, which could have implications for disorders related to pigmentation (Gaudel et al., 2020 ). Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex.: This study utilizes 2-Amino-2-norbornanecarboxylic acid to elucidate the structure of a key amino acid transporter, which is crucial for understanding nutrient uptake and its implications in various diseases (Yan et al., 2019 ).
Biochem/physiol Actions:	2-Amino-2-norbornanecarboxylic acid (BCH) is a Na(+)-independent system L specific substrate used with other system specific substrates such as the system A specific substrate α-(methylamino) isobutyric acid and system N specific substrate L-glutamic acid gamma-monohydroxamate to help identify, differentiate and characterize amino acid transport systems in cells.
General description:	2-Amino-2-norbornanecarboxylic acid is a potential large amino acid transporters inhibitor. It may suppress tumor progression and apoptosis.
Packaging:	1 g in glass bottle
Packaging:	100, 250 mg in glass insert

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

mp	>300 °C (lit.)
UNSPSC	12352106

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