Aconitine
SIGMA/A8001 - ≥95% (HPLC), crystalline
Synonym: Acetylbenzoylaconine
CAS Number: 302-27-2
Empirical Formula (Hill Notation): C34H47NO11
Molecular Weight: 645.74
EC Number: 206-121-7
MDL Number: MFCD00082375
Linear Formula: C34H47NO11
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A8001-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A8001-250MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A8001-25MG
| assay | ≥95% (HPLC) |
| color | white |
| form | crystalline |
| InChI | 1S/C34H47NO11/c1-7-35-15- |
| InChI key | XFSBVAOIAHNAPC-VBUFWTEXSA |
| Quality Level | 200  |
| SMILES string | CCN1C[C@]2(COC)[C@H](O)C[ |
| solubility | ethanol: 35 mg/mL |
| H2O: 0.3 mg/mL |
| Application: | Aconitine has been used: • to study its cardiotoxic effects along the pericardium meridian (PM) on cardiac rhythm in rabbits • as a standard in high-performance thin layer chromatography (HPTLC) fingerprinting method • in the aconitine-based lipo-alkaloids semi-synthesis |
| Application: | Aconitine is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization and blocking the release of neurotransmitters. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection. |
| Biochem/physiol Actions: | Aconitine is a diesterditerpene alkaloid found abundantly in the plant Aconitum genera. It possesses analgesic, antipyretic and antirheumatic activity. Aconitine is involved in blocking neurotransmission. It acts as a neurotoxin as well as a cardiotoxin. Aconitine triggers ventricular tachycardia (VT) and ventricular fibrillation (VF). It interacts with voltage-dependent Na+ channels which results in the depolarization of membranes. Aconitine may exhibit therapeutic effects against systemic lupus erythematosus (SLE). It also inhibits the reuptake of norepinephrine. |
| Biochem/physiol Actions: | Neurotoxin. Activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection. In cultured ventricular myocytes, aconitine increases the duration of the action potential and induces the appearance of early after depolarization. |
| Packaging: | 5, 25, 100, 250 mg in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300 + H330 |
| Precautionary statements | P301 + P310 + P330 - P304 + P340 + P310 |
| Hazard Codes | T+ |
| Risk Statements | 26/28 |
| Safety Statements | 24-45 |
| RIDADR | UN 1544PSN1 6.1 / PGI |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| UNSPSC | 12352200 |