Allopurinol
SIGMA/A8003 - xanthine oxidase inhibitor
Synonym: 1H-
CAS Number: 315-30-0
Empirical Formula (Hill Notation): C5H4N4O
Molecular Weight: 136.11
EC Number: 206-250-9
MDL Number: MFCD00599413
Linear Formula: C5H4N4O
Product Type: Chemical
assay | ≥99% (TLC) |
biological source | synthetic (organic) |
form | powder |
InChI | 1S/C5H4N4O/c10-5-3-1-8-9- |
InChI key | OFCNXPDARWKPPY-UHFFFAOYSA |
mp | >300 °C (lit.) |
Quality Level | 200 |
SMILES string | O=C1NC=Nc2[nH]ncc12 |
solubility | 1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow |
storage temp. | room temp |
Application: | Allopurinol has been used: • to decrease the uric acid levels and study its effect on renal injury and inflammation in mice • as a xanthine oxidase inhibitor to test panton-valentine leukocidin (PVL) neutrophil extracellular traps (NETosis) dependence on different enzymes, channels, or organelles using human polymorphonuclear cells (hPMNs) • as a reference standard to study the inhibitory effect of olive leaf components on xanthine oxidase in vitro |
Application: | Allopurinol is suitable for:• intravenous injection in mice for inhibition of xanthine oxidase • use as an inhibitor of xanthine oxidase • use as a positive control in xanthine oxidase inhibition assay • use in the preparation of University of Wisconsin solution for osmotic stabilization to enhance the density differences between islets and acinar fragments during porcine islet purification |
Biochem/physiol Actions: | Allopurinol is a purine analog that inhibits certain enzymes involved in purine metabolism. It is known to reduce the synthesis of uric acid in the body. Allopurinol mediated inhibition of xanthine oxidase exhibits anti-inflammatory effects on atherosclerosis, acute lung injury, and congestive heart failure. |
Biochem/physiol Actions: | Inhibitor of xanthine oxidase and de novo pyrimidine biosynthesis. A classical agent in treatment of hyperuricemia and gout. |
Packaging: | 5, 25 g in glass bottle |
Symbol | GHS06 |
Signal word | Danger |
Hazard statements | H301 - H317 |
Precautionary statements | P280 - P301 + P310 + P330 - P302 + P352 |
Hazard Codes | T |
Risk Statements | 25-43 |
Safety Statements | 28-36/37-45 |
RIDADR | UN 2811 6.1 / PGIII |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥99% (TLC) |
mp | >300 °C (lit.) |
Storage Temp. | room temp |
UNSPSC | 12352202 |