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Altanserin hydrochloride hydrate

SIGMA/A8106 - ≥98% (HPLC), solid

Synonym: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone hydrochloride hydrate

CAS Number: 76330-71-7 (free base)
Empirical Formula (Hill Notation): C22H22FN3O2S · HCl · xH2O
Molecular Weight: 447.95 (anhydrous basis)
MDL Number: MFCD11045280
Linear Formula: C22H22FN3O2S · HCl · xH2O
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-A8106-10MG 10 mg
$170.00
1/EA
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45-A8106-50MG 50 mg
$666.00
1/EA
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assay ≥98% (HPLC)
form solid
InChI 1S/C22H22FN3O2S.ClH.H2O/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;;/h1-8,16H,9-14H2,(H,24,29);1H;1H2
InChI key MFGBKMPKRJCLPK-UHFFFAOYSA-N
Quality Level 100 
SMILES string O.Cl.Fc1ccc(cc1)C(=O)C2CCN(CC2)CCN3C(=S)Nc4ccccc4C3=O
solubility DMSO: >5 mg/mL
  H2O: insoluble
storage temp. 2-8°C
Application: Altanserin hydrochloride hydrate has been used in the pretreatment of rat brain samples and as a non-radioactive control in the calibration curve preparation for quantifying [18F]altanserin in high-performance liquid chromatography.
Application: Altanserin hydrochloride hydrate is a specific 5-HT2/serotonergic antagonist and has been used in a study to assess serotonin release capacity in the human brain.
Biochem/physiol Actions: Altanserin hydrochloride hydrate is a specific 5-HT2/serotonergic antagonist.
Biochem/physiol Actions: The radioligand of altanserin, [18F]altanserin is useful as a positron emission tomography (PET)-radioligand for the visualization and quantification of serotonin2A (5-HT2A) receptors.
Packaging: 10, 50 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H319
Precautionary statements P305 + P351 + P338
Hazard Codes Xi
Risk Statements 36
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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