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AGK2

SIGMA/A8231 - ≥97% (HPLC), powder

Synonym: 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

CAS Number: 304896-28-4
Empirical Formula (Hill Notation): C23H13Cl2N3O2
Molecular Weight: 434.27
MDL Number: MFCD01909444
Linear Formula: C23H13Cl2N3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A8231-5MG 5 mg
 $174.00
1/EA		 Add To Favorites
45-A8231-25MG 25 mg
 $688.00
1/EA		 Add To Favorites

 

assay ≥97% (HPLC)
form powder
InChI 1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+
InChI key SVENPFFEMUOOGK-SDNWHVSQSA-N
Quality Level 100 
SMILES string Clc1ccc(Cl)c(c1)-c2ccc(C=C(/C#N)C(=O)Nc3cccc4ncccc34)o2
solubility DMSO: 2 mg/mL, clear (warmed)
  H2O: insoluble
storage temp. room temp
Application: AGK2 is a SIRT2 inhibitor. AGK2 has been used in a study to determine that SIRT2 inhibition induces cell death and decreases the intracellular ATP level. AGK2 also rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models.
Biochem/physiol Actions: AGK2 is a SIRT2 inhibitor. AGK2 rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models. IC50 for SIRT2 = 3.5 uM. AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRT3. AGK2 may be the most selective SIRT2 inhibitor available.
Biochem/physiol Actions: AGK2 is a SIRT2 inhibitor; rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xi
Risk Statements 36
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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