Ampicillin sodium salt

SIGMA/A8351 - BioXtra, suitable for cell culture

Synonym: D-(−)-α-Aminobenzylpenicillin sodium salt

CAS Number: 69-52-3
Empirical Formula (Hill Notation): C₁₆H₁₈N₃NaO₄S
Molecular Weight: 371.39
EC Number: 200-708-1
MDL Number: MFCD00064313
Linear Formula: C₁₆H₁₈N₃NaO₄S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-A8351-5G	5 g	$95.50 1/EA		Add To Favorites
45-A8351-25G	25 g	$381.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
color	white to off-white
form	powder
impurities	endotoxin, tested
InChI	1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1
InChI key	KLOHDWPABZXLGI-YWUHCJSESA-M
mode of action	cell wall synthesis \| interferes
mp	215 °C (dec.) (lit.)
product line	BioXtra
Quality Level	200
SMILES string	[Na+].CC1(C)SC2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C([O-])=O
storage temp.	2-8°C
technique(s)	cell culture \| mammalian: suitable

Application:	Ampicillin is a semi-synthetic derivative of penicillin that functions as a broad-spectrum antibiotic. It has been used to study antibiotic resistance and penetration limitations, the synergy between multiple antibiotics, certain bloodstream infections, and has been used to develop PCR assays to detect resistance genes in cerebrospinal fluid.
Biochem/physiol Actions:	Mode of Action: This is a ß-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Mode of Resistance: Administration with ß-lactamase cleaves the ß-lactam ring of Ampicillin and inactivates it. Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol.
Disclaimer:	This product has been reported stable as supplied at 25°C at 43% and 81% relative humidity for six weeks. Additional studies have shown that the stability of Ampicillin in solution is a function of pH, temperature and the identity of the buffer. It′s activity is quickly lost when stored above pH 7. Optimal storage conditions are suggested as 2-8°C, and pH 3.8-5 where its activity was retained at 90%+ for a week.
General description:	Chemical structure: ß-lactam
Other Notes:	Keep container tightly closed in a dry and well-ventilated place, hygroscopic.
Preparation Note:	Ampicillin is reported as slightly soluble in water, practically insoluble in alcohol, chloroform, ether and fixed oils but soluble in dilute acids or bases. The solution should not be autoclaved; a stock solution should be sterilized through filtration and stored frozen, where it will be stable for months.

Symbol	GHS08
Signal word	Danger
Hazard statements	H317 - H334
Precautionary statements	P261 - P280 - P342 + P311
Hazard Codes	Xn
Risk Statements	42/43
Safety Statements	22-36/37-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

mp	215 °C (dec.) (lit.)
Storage Temp.	2-8°C
UNSPSC	51281716

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