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Acylase I from porcine kidney

SIGMA/A8376 - Grade II, salt-free, lyophilized powder, 300-1,500 units/mg protein

Synonym: Aminoacylase; N-Acylamino acid amidohydrolase

CAS Number: 9012-37-7
EC Number: 232-732-3
MDL Number: MFCD00081285
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A8376-1G 1 g
 $267.00
1/EA		 Add To Favorites
45-A8376-10G 10 g
 $1460.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A8376-10G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A8376-1G

 

form salt-free, lyophilized powder
Quality Level 200 
specific activity 300-1,500 units/mg protein
storage temp. −20°C
type Grade II
UniProt accession no. P37111 
Analysis Note: Protein determined by biuret.
Application: Acylase I from porcine kidney has been used to study the acylase I-catalyzed deacetylation of various S-alkyl-N-acetyl-L-cysteines and their carbon and oxygen analogues . Acylase I may be useful to catalyze N-acetyl amino acids to enantiomerically pure L-amino acids .
Biochem/physiol Actions: Acylase I is a zinc metalloprotein that catalyzes the kinetic resolution of unnatural and rarely occurring α-amino acids. Its enantioselectivity for the hydrolysis of N-acyl L-α-amino acids is nearly absolute, yet it accepts substrates having a wide range of structure and functionality. Acylase I catalyzes the deacetylation of N-acetyl-L-cysteine and S-alkyl-N-acetyl-L-cysteines. n-Butylmalonic acid is an inhibitor of acylase I. S-alkyl-N-acetyl-L-cysteines with short (C0-C3) and unbranched S-alkyl substituents have been found to be good acylase I substrates.
Other Notes: One unit will hydrolyze 1.0 μmole of N-acetyl-L-methionine per hr at pH 7.0 at 25 °C.
Packaging: 1, 10 g in poly bottle
activity specific activity: 300-1,500 units/mg protein
Storage Temp. −20°C
Enzyme Commission (EC) Number 3.5.1.14   ( BRENDA  | IUBMB  )
UNSPSC 12352204

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