Amitriptyline hydrochloride

SIGMA/A8404 - ≥98% (TLC), powder

CAS Number: 549-18-8
Empirical Formula (Hill Notation): C₂₀H₂₃N · HCl
Molecular Weight: 313.86
EC Number: 208-964-6
MDL Number: MFCD00012537
Linear Formula: C₂₀H₂₃N · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-A8404-10G	10 g	$50.30 1/EA		Add To Favorites
45-A8404-25G	25 g	$121.00 1/EA		Add To Favorites
45-A8404-100G	100 g	$317.00 1/EA		Add To Favorites
45-A8404-250G	250 g	$506.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (TLC)
color	white to off-white
form	powder
InChI	1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
InChI key	KFYRPLNVJVHZGT-UHFFFAOYSA-N
originator	Bristol-Myers Squibb
Quality Level	200
SMILES string	Cl[H].CN(C)CCC=C1c2ccccc2CCc3ccccc13
solubility	ethanol: soluble
	H₂O: soluble
storage temp.	2-8°C

Application:	Amitriptyline hydrochloride has been used: • as an antidepressant to study its effects on social behavior and memory in transgenic for acid sphingomyelinase (t-ASM) mice • as a tricyclic antidepressant to analyze its effects on glucocorticoid receptor function in whole human blood • as an anti-depressant to study its effects on scratching and locomotion behavior in chloroquine-induced mouse
Biochem/physiol Actions:	Amitriptyline hydrochloride shows therapeutic effects against anxiety, maniac depression, and involutional melancholia. It possesses antihistaminic, anticholinergic, and antiserotonimic properties. Amitriptyline hydrochloride acts as an amphiphilic agent and exhibits neuroleptic activity.
Biochem/physiol Actions:	Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with K_is of 100 nM and 14.7 nM, respectively; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.
Biochem/physiol Actions:	Tricyclic antidepressant; norepinephrine and serotonin transporter inhibitor; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.
Features and Benefits:	Shelf-life of the powder is at least three years.

Symbol	GHS06,GHS08,GHS09
Signal word	Danger
Hazard statements	H301 - H319 - H361d - H410
Precautionary statements	P201 - P273 - P301 + P310 + P330 - P305 + P351 + P338
Hazard Codes	Xn,N
Risk Statements	22-36-50/53
Safety Statements	26-60-61
RIDADR	UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s.,
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (TLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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