Amiodarone hydrochloride

SIGMA/A8423 - ≥98%

Synonym: (2-Butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone hydrochloride; 2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride

CAS Number: 19774-82-4
Empirical Formula (Hill Notation): C₂₅H₂₉I₂NO₃ · HCl
Molecular Weight: 681.77
EC Number: 243-293-2
MDL Number: MFCD00069204
Linear Formula: C₂₅H₂₉I₂NO₃ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A8423-1G	1 g	$84.60 1/EA	Add To Favorites
45-A8423-5G	5 g	$324.00 1/EA	Add To Favorites
45-A8423-10G	10 g	$535.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A8423-1G

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98%
form	powder
InChI	1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H
InChI key	ITPDYQOUSLNIHG-UHFFFAOYSA-N
originator	Wyeth
Quality Level	200
SMILES string	C(=O)(C=1C=2C(OC1CCCC)=CC=CC2)C3=CC(I)=C(OCCN(CC)CC)C(I)=C3.Cl
storage temp.	2-8°C

Application:	Amiodarone hydrochloride has been used to study its interaction with cysteamine to stimulate autophagy in cultured biosensor cell lines. It has also been used in larval and adult organ toxicogenomic screening to analyze the transcriptional effects of pharmaceuticals.
Application:	Amiodarone hydrochloride is a non-selective ion channel blocker. Amiodarone induces an immediate influx of Ca²⁺ in Saccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. Amiodarone hydrochloride has also been used in a study to determine concentrations of thyroid disrupting substances in effluents from wastewater treatment plants.
Biochem/physiol Actions:	Non-selective ion channel blocker. Amiodarone induces an immediate influx of Ca²⁺ in Saccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
Features and Benefits:	This compound was developed by Wyeth . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	CYP2C8/9 and CYP3A family (minor pathway) inhibitor and substrate; CYP2D6, CYP3A family, CYP2D6, CYP2A6, CYP2B6 desethyl-form inhibitor
Packaging:	1, 5, 10 g in poly bottle

Symbol	GHS07,GHS08,GHS09
Signal word	Warning
Hazard statements	H312 + H332 - H315 - H319 - H361d - H373 - H410
Precautionary statements	P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
Hazard Codes	Xn
Risk Statements	20/21/22
Safety Statements	36
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98%
Storage Temp.	2-8°C
UNSPSC	12352200

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