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N-(p-Amylcinnamoyl)anthranilic acid

SIGMA/A8486 - ≥98% (HPLC)

Synonym: 2-[[1-oxo-3-(4-Pentylphenyl)-2-propen-1-yl]amino]-benzoic acid; ACA; N-(4-Pentylcinnamoyl)anthranilic acid

CAS Number: 99196-74-4
Empirical Formula (Hill Notation): C21H23NO3
Molecular Weight: 337.41
MDL Number: MFCD00211365
Linear Formula: C21H23NO3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A8486-5MG 5 mg
 $97.30
1/EA		 Add To Favorites
45-A8486-25MG 25 mg
 $369.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to off-white
form powder
InChI 1S/C21H23NO3/c1-2-3-4-7-16-10-12-17(13-11-16)14-15-20(23)22-19-9-6-5-8-18(19)21(24)25/h5-6,8-15H,2-4,7H2,1H3,(H,22,23)(H,24,25)/b15-14+
InChI key GAMRBCZMOOMBSQ-CCEZHUSRSA-N
Quality Level 100 
SMILES string CCCCCc1ccc(C=CC(=O)Nc2ccccc2C(O)=O)cc1
solubility DMSO: ≥20 mg/mL
storage temp. room temp
Application: N-(p-Amylcinnamoyl)anthranilic acid has been used as a transient receptor potential cation channel subfamily M member 2 (TRPM2) inhibitor, in studying its role in regulating the production of reactive oxygen species (ROS).
Application: N-(p-Amylcinnamoyl)anthranilic acid is a broad spectrum PLA2 inhibitor and TRP channel blocker. N-(p-Amylcinnamoyl)anthranilic acid has been used to study the functional expression of TRPM2 channels in dopaminergic SNc neurons.
Biochem/physiol Actions: Broad spectrum phospholipase A2 (PLA2) inhibitor and TRP channel blocker.
Features and Benefits: This compound is featured on the Phospholipase A2  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: N-(p-Amylcinnamoyl)anthranilic acid (ACA) functions as a broad spectrum phospholipase A2 inhibitor and blocks transient receptor potential (TRP) channels. It inhibits calcium activated chloride current in cardiac ventricular myocytes. ACA regulates various ion channels.
Packaging: 5, 25 mg in glass bottle
Symbol GHS09  GHS09
Signal word Warning
Hazard statements H410
Precautionary statements P273 - P501
Hazard Codes N
Risk Statements 50/53
Safety Statements 60-61
RIDADR UN 3077 9 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352106

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