Adenine
SIGMA/A8626 - ≥99%
Synonym: 6-Aminopurine; Vitamin B4
CAS Number: 73-24-5
Empirical Formula (Hill Notation): C5H5N5
Molecular Weight: 135.13
EC Number: 200-796-1
MDL Number: MFCD00041790
Linear Formula: C5H5N5
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A8626-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A8626-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A8626-1KG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A8626-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A8626-5G
| assay | ≥99% |
| biological source | synthetic |
| color | white to off-white |
| form | powder |
| InChI | 1S/C5H5N5/c6-4-3-5(9-1-7- |
| InChI key | GFFGJBXGBJISGV-UHFFFAOYSA |
| mp | >360 °C (lit.) |
| Quality Level | 200  |
| SMILES string | Nc1ncnc2[nH]cnc12 |
| solubility | 0.5 M HCl: soluble 20 mg/mL, Grade III, colorless to faint yellow or tan |
| storage temp. | room temp |
| technique(s) | UV/Vis spectroscopy: suitable |
| Application: | Adenine is suitable for use: • as a component of boron-deficient media to grow yeast in order to assess whether yeast growth is stimulated by boron • as a food supplement for adult rats to investigate the effects of dietary adenine overload • as a nucleic acid base supplement in the basal media used to grow anaerobic Bacillus mojavensis and Bacillus subtilis in a study to show that DNA or deoxyribonucleosides are required for the anaerobic growth of these bacteria • as an additive to investigate the effects of adenine on CH4 production and on fermentation by ruminal batch cultures from nonlactating Holstein cows • as a part of adenine diet in rats in a study to identify blood markers for early stages of adenine-induced chronic kidney disease (CKD) |
| Biochem/physiol Actions: | Adenine is essential for many in vivo and in vitro biochemical processes. Adenine is converted to adenosine with ribose. On phosphorylation, it forms AMP, ADP and ATP. ATP is the energy currency of the cell and is required during cellular metabolism. Adenine is metabolized to is 2,8-dihydroxyadenine, which on accumulation in proximal tubules leads to the induction of chronic kidney disease (CKD) with severe anemia in rats. Adenine based derivatives elicit antiviral functionality against dsDNA viruses and are exploited for generating antiviral scaffolds. |
| General description: | Adenine is a purine nucleobase. It is part of DNA, and RNA. Adenine is also a component of cofactors (NAD, FAD) and signaling molecules (cAMP). |
| Packaging: | 1 kg in poly bottle |
| Packaging: | 1, 5, 25, 100 g in poly bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264 - P270 - P301 + P310 - P405 - P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 26-36 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Purity | ≥99% |
| mp | >360 °C (lit.) |
| Storage Temp. | room temp |
| UNSPSC | 41106305 |