Antimycin A from Streptomyces sp.
SIGMA/A8674
Synonym: Antipiricullin
CAS Number: 1397-94-0
MDL Number: MFCD01779723
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A8674-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A8674-25MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A8674-50MG
| antibiotic activity spectrum | fungi |
| form | powder |
| InChI | 1S/C28H40N2O9/c1-6-7-8-9- |
| InChI key | UIFFUZWRFRDZJC-RBVQMQRASA |
| mode of action | enzyme | inhibits |
| Quality Level | 300  |
| SMILES string | [H]C(=O)Nc1cccc(C(=O)N[C@ |
| storage temp. | −20°C |
| Application: | Antimycin A from Streptomyces sp. has been used: • as a respiratory chain inhibitor in neuronal cultures • in organello ATP production assay in Trypanosoma brucei cells • in respiration assay for papillary thyroid carcinoma (PTC) cell lines |
| Application: | Antimycin A has been used to study the specific sites of reactive oxygen species production in mitochondria isolated from skeletal muscle of chronic obstructive pulmonary disease patients, and its relationship with local oxidative stress induced by exercise |
| Biochem/physiol Actions: | Inhibitor of electron transfer at complex III. Induces apoptosis. |
| General description: | Antimycin is an antibiotic produced by Streptomyces species. It inhibits mitochondrial electron transport chain complex III and favors reactive oxygen species (ROS) production, impairing mitochondrial depolarization. It inhibits nitric oxide-mediated apoptosis and modulatescytochrome C release. It suppresses tumorigenesis in lung cancer cells and could be a potential therapeutic agent.Antimycin A serves as a positive control for superoxide generation. |
| General description: | Chemical structure: peptide |
| Other Notes: | 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research  |
| Packaging: | 25, 50, 100 mg in glass bottle |
| Quality: | A mixture of antimycins. |
| Symbol |   GHS06,GHS09 |
| Signal word | Danger |
| Hazard statements | H300 - H400 |
| Precautionary statements | P264 - P270 - P273 - P301 + P310 - P391 - P405 |
| Hazard Codes | T,N |
| Risk Statements | 25-50 |
| Safety Statements | 26-36/37/39-45-61 |
| RIDADR | UN3462 - class 6.1 - PG 2 - EHS - Toxins, extracted from living |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |