Alprazolam
SIGMA/A8800
Synonym: 8-
CAS Number: 28981-97-7
Empirical Formula (Hill Notation): C17H13ClN4
Molecular Weight: 308.76
EC Number: 249-349-2
MDL Number: MFCD00078881
Linear Formula: C17H13ClN4
Product Type: Chemical
application(s) | forensics and toxicology pharmaceutical (small molecule) veterinary |
drug control | USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal) |
form | powder |
InChI | 1S/C17H13ClN4/c1-11-20-21 |
InChI key | VREFGVBLTWBCJP-UHFFFAOYSA |
originator | Johnson & Johnson |
Quality Level | 200 |
SMILES string | Cc1nnc2CN=C(c3ccccc3)c4cc |
solubility | H2O: insoluble |
methanol: soluble | |
technique(s) | gas chromatography (GC): suitable |
HPLC: suitable |
Biochem/physiol Actions: | Alprazolam binds the GABAA receptor at the benzodiazepine site, which is different than the ligand-binding site at which GABA binds. Alprazolam has been shown to be an anxiolytic (anti-anxiety agent) as well as having anticonvulsant, muscle relaxant and antidepressant activity. |
Features and Benefits: | This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
Features and Benefits: | This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
Features and Benefits: | This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
General description: | Alprazolam is a triazole-containing benzodiazepine that is related to diazepam and other 1,4-benxodiazepines. Like other benzodiazepines, Alprazolam is a GABAergic agonist that modulates GABAA receptors. GABAA receptors in the central nervous system are ligand-gated ion channels that are bound by the stimulatory neurotransmitter GABA; binding of this ligand allows ion movement through the channel and results in neurotransmission inhibition. |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H302 |
Hazard Codes | Xn |
Risk Statements | 22 |
Safety Statements | 36 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
UNSPSC | 12352200 |