Apicidin
SIGMA/A8851 - ≥98% (HPLC), from microbial
Synonym: Cyclo[(2S)
CAS Number: 183506-66-3
Empirical Formula (Hill Notation): C34H49N5O6
Molecular Weight: 623.78
MDL Number: MFCD03452661
Linear Formula: C34H49N5O6
Product Type: Chemical
antibiotic activity spectrum | parasites |
assay | ≥98% (HPLC) |
biological source | microbial |
form | solid |
InChI | 1S/C34H49N5O6/c1-5-22(3)3 |
InChI key | JWOGUUIOCYMBPV-PYAAAQPJSA |
mode of action | enzyme | inhibits |
Quality Level | 200 |
shipped in | wet ice |
SMILES string | [H][C@]12CCCCN1C(=O)[C@@H |
solubility | DMSO: ~1 mg/mL |
sterility | non-sterile |
storage temp. | −20°C |
Application: | Apicidin has been used as a histone deacetylase 2 (HDAC2) inhibitor to study its effects on 5-lipoxygenase (5-LO) mRNA expression in cell lines of Mono Mac6. It has also been used to study the effects of toll-like receptor 8 (TLR-8) stimulation and histone modification on the expression of an activator protein 1 [AP-1] family member(Fra-2) and tissue inhibitor of metalloproteinases 1 (TIMP-1) in monocytes. |
Biochem/physiol Actions: | Apicidin is a potent inhibitor of histone deacetylase (HDAC). It particularlyinhibits histone deacetylase 1 and 3 (HDAC1 and HDAC3). Apicidin exhibits anti-protozoal activity against apicomplexan metabolite produced by parasites. It also possesses anti-proliferative activity against several cancer cell lines. Apicidin shows anti-cancer activity against human acute promyelocytic leukemia cell. |
Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
General description: | Apicidin is a cyclic tetrapeptide fungal metabolite. |
Packaging: | 1, 5 mg in glass bottle |
Hazard Codes | T+ |
Risk Statements | 26/27/28 |
Safety Statements | 22-26-36/37/39-45 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |