Anti-phospho-APP (pThr668) antibody produced in rabbit
SIGMA/A9103 - affinity isolated antibody, aqueous glycerol solution, 10 blots
MDL Number: MFCD06798482
Product Type: Chemical
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| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | aqueous glycerol solution |
| mol wt | antigen 100-140 kDa |
| Quality Level | 200  |
| species reactivity | human |
| storage temp. | −20°C |
| technique(s) | western blot: 1:1000 using CAD cells transfected with wild type vs. T668A mutant APP. |
| UniProt accession no. | P05067  |
| usage | 10 blots |
| Application: | Cultured cortical neurons were immunostained for APP using rabbit anti-phospho-APP (pThr688) antibody. |
| Application: | Rabbit Anti-phospho-APP (pThr668) antibody can be used for western blot applications at a dilution of 1:1,000. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Amyloid precursor proteins (APPs) are transmembrane glycoproteins that are found in a wide range of tissues. APPs have 3 main isoforms, namely, APP695, APP751 and APP770 that are derived from alternative splicing events in cells. Accumulation of the cleavage products of APP, such as the β-amyloid peptide, can cause Alzheimer′s disease. Rabbit Anti-phospho-APP (pThr668) antibody binds to human APP phosphorylated at Thr668. Mouse, rat and frog APP are 100% homologous. |
| Immunogen: | synthetic phosphopeptide corresponding to the region of APP containing threonine 688. |
| Physical form: | Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 50% glycerol, 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |