ADP-ribosylcyclase
SIGMA/A9106 - 1000-3000 units/mg protein
Synonym: Adenosine diphosphoribose cyclase from Aplysia californica
CAS Number: 135622-82-1
MDL Number: MFCD00212894
Product Type: Chemical
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| application(s) | genomic analysis |
| assay | ≥80 μ protein/vial (BCA) |
| biological source | (Aplysia californica) |
| composition | Protein, ≤10% |
| concentration | ≤10% (BCA method) |
| form | lyophilized powder |
| packaging | vial of ≥80 μg protein |
| Quality Level | 200  |
| specific activity | 1000-3000 units/mg protein |
| storage condition | dry at room temperature |
| storage temp. | −20°C |
| suitability | suitable for enzyme test |
| Application: | ADP-ribosylcyclase is a Ca2+ signaling second messenger. It may be used to study calcium signaling and has been used to research morphine antinociception and tolerance . |
| Biochem/physiol Actions: | ADP-ribosylcyclase is an intracellular calcium regulator that cyclizes NAD into cADPR. It is thought that the majority of ADP-ribosylcyclase activity in the brain is linked to CD38. Nicotinamide is a known inhibitor of CD38 ADP-ribosylcyclase activity . |
| Other Notes: | One unit will produce 1 μmole of cyclic ADP ribose from β-NAD+ in 5 minutes at pH 7.0 and 25°C. |
| Physical form: | Lyophilized powder containing trehalose, potassium phosphate and dithiothreitol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥80 μ protein/vial (BCA) |
| activity | specific activity: 1000-3000 units/mg protein |
| Storage Temp. | −20°C |
| UNSPSC | 12352204 |