Angiotensin Fragment 1-7 acetate salt hydrate

SIGMA/A9202 - ≥90% (HPLC), powder

Empirical Formula (Hill Notation): C₄₁H₆₂N₁₂O₁₁ · xC₂H₄O₂ · yH₂O
Molecular Weight: 899.00 (anhydrous free base basis)
MDL Number: MFCD00153513
Linear Formula: C₄₁H₆₂N₁₂O₁₁ · xC₂H₄O₂ · yH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-A9202-1MG	1 mg	$87.10 1/EA		Add To Favorites
45-A9202-5MG	5 mg	$311.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥90% (HPLC)
form	powder
InChI	1S/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)
InChI key	PVHLMTREZMEJCG-UHFFFAOYSA-N
Quality Level	200
SMILES string	CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(Cc2cnc[nH]2)C(=O)N3CCCC3C(O)=O
storage temp.	−20°C
UniProt accession no.	P01019

Amino Acid Sequence:	Asp-Arg-Val-Tyr-Ile-His-Pro
Application:	Angiotensin Fragment 1-7 acetate salt hydrate has been used: • to evaluate its effects on a rat model of ventilator-induced diaphragmatic dysfunction (VIDD) with neuromuscular blocking agent infusion • to unilaterally inject into the lateral preoptic area (LPA) to study its effects on intravesical pressure, arterial pressure, heart rate, and renal conductance in the female rats • to study its association with influenza A virus (IAV) infection
Biochem/physiol Actions:	Angiotensin fragment 1-7 is a biologically active heptapeptide of the renin-angiotensin system (RAS). It is associated with anti-inflammatory and anti-fibrotic effects in many inflammatory diseases such as asthma, dyslipidemia, renal injury, arthritis, and lung fibrosis. Angiotensin fragment 1-7 acts as a pro-resolving mediator and induces resolution of inflammation via Mas receptor (MasR). It is responsible for relaxation in several vascular beds. Angiotensin fragment 1-7 has a dual action of an angiotensin II type 1 (AT1) receptor agonist and antagonist depending on the presence of angiotensin II. It also serves as a substrate for angiotensin-converting enzyme (ACE). Sometimes, angiotensin fragment 1-7 prevents ACE activity leading to decreased angiotensin II generation and improved bradykinin-induced vasodilatation.
Other Notes:	Lyophilized from 0.5% acetic acid
Packaging:	1, 5 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥90% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352202

Choose a favorite list for this item:

Catalog Number	Description	Price

		$

Please choose a list :

Continue Shopping

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.