α1-Antichymotrypsin from human plasma
SIGMA/A9285 - ≥92.5% (SDS-PAGE), lyophilized powder
CAS Number: 141176-92-3
MDL Number: MFCD00162030
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
| assay | ≥92.5% (SDS-PAGE) |
| biological source | human plasma |
| form | lyophilized powder |
| mol wt | 55-66 kDa |
| Quality Level | 200  |
| storage temp. | −20°C |
| technique(s) | microbiological culture: suitable |
| UniProt accession no. | P01011  |
| Application: | α1-Antichymotrypsin from human plasma has been used as a component in yeast extract peptone dextrose broth (YEPD) for biofilm dispersion assays. |
| Biochem/physiol Actions: | Specific inhibitor of chymotrypsin-like serine proteases. |
| Biochem/physiol Actions: | Specific inhibitor of chymotrypsin-like serine proteases. Promotes amyloid-β polymerization in vitro and in vivo. Levels in plasma and cerebrospinal fluid have been found to correlate with progression of dementia in Alzheimer′s patients and induce phosphorylation of tau protein in neurons. |
| Biochem/physiol Actions: | α1-Antichymotrypsin (α1-ACT) can block the functions of various serine proteases like chymotrypsin and cathepsin G. It serves as a potential therapeutic target of endometrial carcinoma (EC). |
| Disclaimer: | RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization. |
| General description: | α1-Antichymotrypsin (α1-ACT) is also known as serpin peptidase inhibitor, clade A member 3 (SERPINA3). It is a 68 kDa serine protease inhibitor, secreted by the liver. It belongs to the serpin superfamily of protease inhibitors. SERPINA3 is located on human chromosome 14q32.1. |
| Packaging: | Package size based on protein content. |
| Physical form: | Lyophilized powder containing Tris buffer salt and NaCl. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥92.5% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |