Artemether
SIGMA/A9361 - ≥98% (HPLC)
Synonym: Dihydroartemisinin methyl ether; Dihydroqinghaosu methyl ether; SM-224
CAS Number: 71963-77-4
Empirical Formula (Hill Notation): C16H26O5
Molecular Weight: 298.37
MDL Number: MFCD00866205
Linear Formula: C16H26O5
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | off-white to light brown |
| form | powder |
| InChI | 1S/C16H26O5/c1-9-5-6-12-1 |
| InChI key | SXYIRMFQILZOAM-HVNFFKDJSA |
| optical activity | [α]/D +155 to +175°, c = 0.5 in methanol |
| originator | Novartis |
| Quality Level | 100  |
| SMILES string | CO[C@H]1OC2O[C@@]3(C)CCC4 |
| solubility | DMSO: ≥20 mg/mL |
| storage temp. | room temp |
| Application: | Artemether has been used: • as an anti-schistosomal compound to test it effect on the larval stages of S. mansoni • to sensitize mouse embryonic fibroblasts (MEFs) and human osteosarcoma HT1080 cells to cysteine starvation (STV)-induced ferroptosis • to stimulate islets and its effect on α to β transdifferentiation |
| Biochem/physiol Actions: | Artemether is a methyl ether derivative of artemisinin. It is used against multi-drug resistant strains of the malaria parasite, Plasmodium falciparum, and shows potential in treatment of schistosomiasis. |
| Biochem/physiol Actions: | Artemisinin possesses a highly reactive endoperoxide bridge, which is core for its therapeutic potential. The endoperoxide bond reacts with iron in the erythrocytes with malarial parasite. This leads to the generation of reactive oxygen species (ROS) directly targeting the parasite. Artemisinin also regulates ferroptosis in tumor cells. The α cell transcription factor Arx expression is reduced by artemether. Prolonged exposure of primary islets also resulted in loss if identity in endocrine cell types and their functionality. |
| Features and Benefits: | This compound was developed by Novartis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: | Artemisinin (ART) is a natural compound present in Artemisia annua, a traditional Chinese plant. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |   GHS02,GHS07 |
| Signal word | Danger |
| Hazard statements | H242 - H302 |
| Precautionary statements | P210 - P235 - P280 - P301 + P312 - P370 + P378 - P410 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 51101500 |