7-Aminoactinomycin D
SIGMA/A9400 - ~97% (HPLC), powder
Synonym: 7-AAD
CAS Number: 7240-37-1
Empirical Formula (Hill Notation): C62H87N13O16
Molecular Weight: 1270.43
MDL Number: MFCD00077295
Linear Formula: C62H87N13O16
Product Type: Chemical
antibiotic activity spectrum | neoplastics |
assay | ~97% (HPLC) |
color | red to very dark purple |
form | powder |
InChI | 1S/C62H87N13O16/c1-26(2)4 |
InChI key | YXHLJMWYDTXDHS-SGILFZQNSA |
mode of action | DNA synthesis | interferes |
Quality Level | 300 |
SMILES string | CC(C)[C@H]1NC(=O)[C@@H](N |
storage temp. | 2-8°C |
Application: | 7-Aminoactinomycin D has been used: • for nuclei visualization in mouse tail skin • as a nuclear stain in imaging flow cytometry for nucleus-protein colocalization • in flow cytometry to determine the level of CD16 (Fc gamma III receptor) and CD32 (Fc gamma II receptor) in epidermal cells |
Features and Benefits: | This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
General description: | 7-Aminoactinomycin D (7-ADD), an analog of actinomycin D (AD) is a membrane-impermeable red fluorescent DNA dye. It can selectively bind GC regions of DNA. 7-ADD is used in flow cytometry to differentiate between viable, apoptotic, and late apoptotic/dead cells. This DNA stain finds its application in chromosome analysis, cell cycle studies, and quantification of apoptosis. |
General description: | Chemical structure: peptide |
Packaging: | 1, 5 mg in serum bottle |
Symbol | GHS06 |
Signal word | Danger |
Hazard statements | H300 |
Precautionary statements | P301 + P330 + P331 + P310 |
RIDADR | UN 3462 6.1 / PGII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ~97% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 41106305 |