7-Aminoactinomycin D

SIGMA/A9400 - ~97% (HPLC), powder

Synonym: 7-AAD

CAS Number: 7240-37-1
Empirical Formula (Hill Notation): C₆₂H₈₇N₁₃O₁₆
Molecular Weight: 1270.43
MDL Number: MFCD00077295
Linear Formula: C₆₂H₈₇N₁₃O₁₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-A9400-1MG	1 mg	$219.00 1/EA		Add To Favorites
45-A9400-5MG	5 mg	$979.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	neoplastics
assay	~97% (HPLC)
color	red to very dark purple
form	powder
InChI	1S/C62H87N13O16/c1-26(2)42-59(85)74-21-17-19-36(74)57(83)70(13)24-38(76)72(15)48(28(5)6)61(87)89-32(11)44(55(81)66-42)68-53(79)34-23-35(63)30(9)51-46(34)65-47-40(41(64)50(78)31(10)52(47)91-51)54(80)69-45-33(12)90-62(88)49(29(7)8)73(16)39(77)25-71(14)58(84)37-20-18-22-75(37)60(86)43(27(3)4)67-56(45)82/h23,26-29,32-33,36-37,42-45,48-49H,17-22,24-25,63-64H2,1-16H3,(H,66,81)(H,67,82)(H,68,79)(H,69,80)/t32-,33-,36+,37+,42-,43-,44+,45+,48+,49?/m1/s1
InChI key	YXHLJMWYDTXDHS-SGILFZQNSA-N
mode of action	DNA synthesis \| interferes
Quality Level	300
SMILES string	CC(C)[C@H]1NC(=O)[C@@H](NC(=O)c2cc(N)c(C)c3OC4=C(C)C(=O)C(N)=C(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]6CCCN6C(=O)[C@H](NC5=O)C(C)C)C4=Nc23)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]7CCCN7C1=O
storage temp.	2-8°C

Application:	7-Aminoactinomycin D has been used: • for nuclei visualization in mouse tail skin • as a nuclear stain in imaging flow cytometry for nucleus-protein colocalization • in flow cytometry to determine the level of CD16 (Fc gamma III receptor) and CD32 (Fc gamma II receptor) in epidermal cells
Features and Benefits:	This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description:	7-Aminoactinomycin D (7-ADD), an analog of actinomycin D (AD) is a membrane-impermeable red fluorescent DNA dye. It can selectively bind GC regions of DNA. 7-ADD is used in flow cytometry to differentiate between viable, apoptotic, and late apoptotic/dead cells. This DNA stain finds its application in chromosome analysis, cell cycle studies, and quantification of apoptosis.
General description:	Chemical structure: peptide
Packaging:	1, 5 mg in serum bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H300
Precautionary statements	P301 + P330 + P331 + P310
RIDADR	UN 3462 6.1 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	~97% (HPLC)
Storage Temp.	2-8°C
UNSPSC	41106305

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